ADAPTASI,JEJAS DAN PENUAAN SEL

Refortinus Zega 170204058

Esra Paulina Silaen 170204018
Robin Syah Putra Halawa 170204002
Meiwan Pasrah Christian H 170204008
Noralissa Nainggolan 170204050
Kartika Pakpahan 170204032

PROGRAM STUDI NERS

FAKULTAS FARMASI & ILMU KESEHATAN
UNIVERSITAS SARI MUTIARA INDONESIA
TAHUN 2018
Cell Adaptation

Adaptation is a reversible change of

the number, size, phenotype,
metabolite activity or cell function
in responding to environmental
changes
.
 Such adaptations can occur in different forms:
•Hypertrophy(Hipertrofia)
Hypertrophy is the increasing size of
cells that cause organs to grow larger.
Physiological enlargement of the uterus
during pregnancy occurs due to plain
muscle hypertrophy and plain muscle
hyperplasia due to the influence of ext.
Examples of pathologic cell hypertrophia
are cardiac enlargement due to
hypertension or aortic valve disease
•Hyperplasia(hiperplasia)
Hyperplasia occurs when
tissues contain cells that are capable
of replicating so that it coincides with
hypertrophy and often occurs
because of the same stimulus.
physiological Hyperplasia
hyperplasia kompensantorik

Hormonal
hyperplasia

Pathological
hyperplasia
caused by hormone stimulus
and increased growth factors
•Atrophia(Atrofia)
Atrophia is the diminution of
cell size resulting in the loss of cell
substance(Atrofia adalah melisutnya
ukuran sel akibatnya hilangnya
substansi sel)

•Metaplasia
Metaplasia is a refersible
change that is an adult type cell
(epithelial or mesenchymal cells)
replaced by other adult type cells
 Cell
jejas/jejas
sell

The cell jejas occur when the cell undergoes severe strees so
that the cell can no longer adapt or when the cell is exposed to
a damaging agent or has an intrinsic abnormality(Jejas sel
terjadi apabila sel mengalami strees yang berat sehingga sel
tersebut tidak dapat lagi beradaptasi atau apabila sel terpapar
pada agen yang merusak atau mengalami abnormallitas
intrinsic)

necrosis
Reversible cell
Cell death.
jejas
apoptosis
 (-) oxygen Genetic
Factors

Chemical Nutrition
Agents Causes Imblans
of Jejas
Sel

Infectious
Physical
agent
Agents

Imonological
Aging
Reactions
 Cell aging

Cell aging results from a progressive decrease in the

lifespan and functional capacity of cells(Penuaan
sel terjadi akibat penurunan progresif masa hidup
dan kapasitas fungsional sel)

Caused by

Defects in protein
hemeostatis
(Cacat pada Reduced cell
DNA damage hemeostatis replication
protein)