FIBROADENOMA

M A M M A E
 01.

1 FIBROADENOMA MAMMAE
The most common tumors of the breast clinically and pathologically
in adolescent and young women but may be discovered at any
age.

4 80%
Under 30 years
A N A T O M Y
 ETIOLOGY AND PATHOGENESIS
01 ESTROGEN
ER-β is expressed by stromal cells
of fibroadenoma and the mRNA
level (Woolcott, 2008).
And that such expressions are related to smooth
muscle differentiation of stromal cells and to the age
of patients (Sapino, 2013)
02 GROWTH HORMONE
The high expression of growth
hormone and growth hormone
receptor in fibroadenoma tissue
indicates their possible role in the
pathogenesis of this tumor (Tanja,
2013)
 02.
CLINICAL FEATURES
 More than 70% of fibroadenomas present as a single mass,

2
and 10%–25% of fibroadenomas present as multiple masses
 Painless
 Smooth
 Mobile
 Rubbery mass with distinct borders usually ranging from 1 cm
to 3 cm in size on the upper outer quadrant of the breast

4
(Cerrato, 2013).
 DIAGNOSIS ULTRASONOGRAPHY
 Typically seen as a well-circumscribed, round to ovoid, or
macrolobulated mass with generally uniform
hypoechogenicity.
 Intralesional sonographically detectable calcification may be
seen in ~ 10% of cases
 Sometimes a thin echogenic rim (pseudocapsule) may be seen
sonographically.

Gambaran USG Fibroadenoma. Tampak massa hipoechoic

yang rata, batas tegas pada sebagian lobus merupakan
khas dari fibroadenoma
 DIAGNOSIS ULTRASONOGRAPHY

Gambaran USG Fibroadenoma. Tampak massa hipoechoic

yang rata, batas tegas dengan bilateral tedpole sign.
 DIAGNOSIS M A M O G R A P H Y
 well-circumscribed discrete oval mass hypodense or
isodense to the breast glandular tissue,
 typically postmenopausal patients may contain calcification,
often producing the classic, coarse popcorn
calcification appearance.

Gambaran mamografi fibroadenoma. Tampak massa

berbatas tegas serta tampak adanya kalsifikasi.
DIAGNOSIS M A M O G R A P H Y
 03.

3 TREATMENTS
 Radial Incision
 Circumaerolar incision

4
 Curve or Semicircular incision (de Jong, 2012)
 04.
DIFFERENTIAL DIAGNOSIS

4
PHYLLODES TUMOUR

Rare fibroepithelial lesions and World Health Organization

subclassified them histologically as benign, borderline, or
malignant

4 0.3- 0.5%
Female breast tumors and have an incidence of
about 2.1 per million, the peak of which occurs in
women aged 45 to 49 years
 PHYLLODES TUMOUR

CLINICAL FEATURES The skin over large tumors may have

dilated veins and a blue discoloration
but nipple retraction is rare

01
The median size of phyllodes tumors is
around 4 cm. 20% of tumors grow larger
than 10 cm (giant phyllodes tumor). Fixation to skin and pectoralis muscles
These tumors can reach sizes up to
05 02 has been reported, but ulceration is
40 cm in diameter uncommon

04 03 More commonly found in upper outer

Rarely presentation may be bilateral
quadrant with an equal propensity to
occur in either breast.
 DIAGNOSIS ULTRASONOGRAPHY
 Inhomogeneous, solid-appearing mass is the most common
manifestation
 A solid mass containing single or multiple, round or cleft
like cystic spaces and demonstrating posterior acoustic
enhancement strongly suggests the diagnosis of phyllodes
tumour
 Vascularisation is usually present in the solid components

Gambaran USG tumor phyllodes. Tampak massa solid dan

kistik, batas tegas dengan gambaran posterior acoustic
shadow.(
 DIAGNOSIS ULTRASONOGRAPHY

Gambaran USG tumor phyllodes. Tampak massa solid dan

kistik, dengan adanya vaskularisasi di sekitar massa
 DIAGNOSIS M A M O G R A P H Y
 Typically seen as non-specific large rounded oval or
lobulated, generally well circumscribed, lesions with
smooth margins.
 A radiolucent halo may be present.
 Calcification (typically coarse and plaque like) may be seen
in a very small proportion.

Gambaran mamografi pada tumor phyllodes, terlihat

adanya massa isodense pada regio kanan bawah.
 FIBROADENOMA MAMMAE VS PHYLLODES TUMOUR

FIBROADENOMA MAMMAE PHYLLODES TUMOUR 03 01

FIBROADENOMA MAMMAE

01

FIBROADENOMA
03 05 PHYLLODES TUMOUR
MAMMAE 01 Size USG  Posterior acoustic shadow
Age
 Vascularisation is usually
present
PHYLLODES TUMOUR
02
04
Mamography
04 FIBROADENOMA MAMMAE
FIBROADENOMA MAMMAE

02
PHYLLODES TUMOUR
PHYLLODES TUMOUR
FIBROADENOMA MAMMAE VS PHYLLODES TUMOUR

FIBROADENOMA MAMMAE PHYLLODES TUMOUR

T H A N K S