Reumatoid atritis

H1A015032
 Pendahuluan
• Rheumatoid arthritis (RA) is the most common
cause of chronic inflammatory joint disease
• The most typical features are a symmetrical
polyarthritis and tenosynovitis, morning
stiffness, elevation of the erythrocyte
sedimentation rate (ESR) and the appearance
of autoantibodies that target
immunoglobulins (rheumatoid factors) in the
serum
 Epidemiologi
• The reported prevalence of RA in most
populations is 1–3 per cent, with a peak
incidence in the fourth or fifth decades
• Women are affected 3 or 4 times more
commonly than men
• the disease is more common (and generally
more severe) in Caucasians living in the urban
communities of Europe and North America
than in the rural populations of Africa
 Penyebab
• (1) genetic susceptibility;
• (2) an immunological reaction, possibly involving a
foreign antigen, preferentially focussed on synovial
tissue;
• (3) an inflammatory reaction in joints and tendon
sheaths;
• (4) the appearance of rheumatoid factors (RF) in the
blood and synovium;
• (5) perpetuation of the inflammatory process; and
• (6) articular cartilage destruction
 Patologi
• Rheumatoid arthritis adalah penyakit sistemik
tetapi lesi yang paling khas terlihat di
sinovium atau dalam nodul rheumatoid.
Sinoviumnya membesar dengan pembuluh
darah baru dan penuh akan sel-sel inflamasi