HYPERURICEMI

(EXCESS URGENT ACID)

 URIC ACID, HYPERURISEMIA

1. Uric acid (vein) is the end product of protein metabolism (purine)

2. Hyperuricemia: excess blood-soluble uric acid concentration (> 6.8
mg / dl) :
Due to overproduction of uric acid or reduced excretion
(expenditure).
Serum concentrations of serum substance are quite common.
 FOR HYPERURICEMIA

1. Overproduction
a. Primary / idiopathic
b. Secondary
a). High intake
b). Increased purine turnover
c). Increased protein degradation
2. Hipoexcretion
a. Primary / idiopathic
b. Secondary
a). Impaired kidney function
b). Hypertension, hyperparathyroid
 SILENT TISSUE DEPOSITION

• 1. Due to the high levels of extracellular fluid,

crystals of monosodium are formed
• 2. Joints and soft tissues
 KRISTAL URAT MONOSODIUM

Influenced by
1. Decrease in uric acid solubility
a. Temperature, low pH
2. Disturbances in joints and jar. Bind
a. Trauma / injury
3. Reabsorpsi air  supersaturasi
a. Kurang gerak sendi (mis. saat tidur)
 GOUT

1. Conditions caused by deposition of uric acid crystals in joints

2. Signed increase in uric acid in the blood & inflammation of
repeated joints (arthritis)
3. Most attack age 4-6 (Men: 9x than women)
 RISK FACTOR
• Age & Gender
• Obesity
• Alcohol
• Hypertension
• Kidney Function Disorder
• Metabolic diseases
• Diet
• Medications: Low-dose aspirin, Diuretics, TB drugs