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PHARMACOKINETICS
REVIEW OF TERMINOLOGY
INTRODUCTION TO PHARMACOKINETICS
Pharmacokinetic parameters:
Peak plasma concentration (Cmax)
• Peak time (tmax)
• Area under curve (AUC)
Pharmacodynemic Parameters :
Minimum effective concentration
Maximum safe concentration
Onset of action
duration of action
Therapeutic range and therapeutic Index
PHARMACOKINETIC PARAMETERS
PEAK PLASMA CONCENTRATION:
The maximum conc. of drug in plasma observed after
administration of dosage form is called peak plasma
concentration.
PEAK TIME:
The time for drug to reach peak conc. in plasma is called time of
peak concentration.
AREA UNDER CURVE:
It represents total integrated area under the plasma level-time
profile and express the total amount of drug that comes into
systemic circulation after its administration.
PHARMACODYNAMIC PARAMETERS
MINIMUM EFFECTIVE CONC.(MEC):
It is defined as minimum conc. Of drug in plasma required to produce therapeutic
effect .The conc. Of drug below MEC is said to be in subtherapeutic level.
ONSET OF ACTION:
The beginning of pharmacologic response is called as onset of action.
DURATION OF ACTION:
The time period for which plasma conc. Of drug remains above MEC is called
duration of action.
THERAPEUTIC RANGE:
The drug conc. Between MEC and MSC represents therapeutic range.
FRACTION OF DRUG ABSORBED
K 10
1
K01 1 K10
Model 3 Two compartment open model,
intravenous bolus administration
K12
2
1
K21
K10
I
Model 4 Two compartment open model,
extravascular administration
K12
K01 1 2
K21
K10
I
CATERNARY MODEL
K12 K23
2 3
K01 1
K21 K32
model independent method
Describe the pharmacokinetics of drug disposition using time
and concentration parameters.
Method can however be applied to any compartment model
provided the drugs or metabolites follow linear kinetics.
The approach based on statistical moments theory.
If one considers the time course of drug concentration in
plasma as a statistical distribution curve, then:
MRT = AUMC
AUC
Where MRT= mean residence time
AUMC=area under first-moment curve
AUC=area under zero-moment curve
PHYSIOLOGICAL MODEL