GROUP 1

1. DHANI RINALDI MAULANA (1608062223)

2. FAHMI HUMAIDI ABDILLAH (1608062215)
3. SATRIYO DWI RAHARJO (1608062224)
4. AGUNG RAHARJO (1608062180)
5. NOVIA FLORISA (1608062261)
6. DINA QOYIMA (1608062240)
7. TANTRI SOFIA FAUZIAH (1608062234)
DEFINITION
Obesity is an imbalance between energy
intake and energy expenditure overtime,
resulting in increased energy storage.
CLASSIFICATION OF WEIGHT ACCORDING
TO BMI

BMI = Body weight/(height/100)2

PATHOPHYSIOLOGY OF OBESITY

Energy intake > energy needed

↑ Adipose Tissue

↑ Leptin in plasma

↓ ↑ Appetite
 Pathophysiology of Obesity

Imbalance Energy

ENERGY Energy Energy

INTAKE Storage Output
TREATMENT ALGORITHM OF OBESITY
HERBAL MEDICINE

1. Black Tea (camellia sinensis)

2. Bitter Orange (citrus aurantium)
 BLACK TEA (CAMELLIA SINENSIS)
Active compound : Theaflavin

Theaflavin significantly decreased lipid accumulation, reduced

fatty acid synthesis, and promoted fatty acid oxidation.
Dosage : 448 g/100 ml
 BITTER ORANGE
Active compound : p-synephrine

• Mechanism of p-synephrine is increasing the resting metabolic rate

• Dosage : 10 – 53 mg /day
 SYNTHETIC MEDICINE : ORLISTATE
• Mechanism of orlistate is reducing the absorption of energy-dense fat by
inhibiting pancreatic and gastric lipases.
• Dosage : 60 mg 3 times a day
• Contraindication : pregnancy , bladder problem, orlistate hipersensitivity
• Side effect : hives; dyspnea; face, lips, tongue, or throat swelling
SIBUTRAMINE

Sibutramine prevented the decrease in energy

expenditure and basal metabolic rate that
follows weight loss.

Contraindication: hypertension, coronary

artery disease, congestive heart failure

Side effect: aritmia, dyspnea, severe headache

Dosage: 10 mg daily