Professional Documents
Culture Documents
Kes
Depart. Patologi Mulut dan Maksilofasial
FKG Unair
Oral Biolog
Faculty of
Mucosal surface is major portal of entry for
pathogens
At least 90% of infectious microorganisms use
the mucosae
as portals of entry
Examples include sexually transmitted infections
caused by HIV,Chlamydia, Neisseria, HSV;
gastrointestinal infection caused by
Helicobacter pylori and Vibrio cholerae;
respiratory infections caused by RSV and
influenza;
Mucosal surfaces can generally be divided
into a
- Type I mucosal surfaces (such as those in
the gut and the lungs)
Epitel : simple columnar epithelium
Major antibody isotype : sIgA
Mucosa associated Lymphoid Tissue
Mucus source : sel Goblet dan kelnjar pada
Crypta
- Type II mucosal surfaces (such as those in
the vagina eyes and , eyes and mouth)
Epitel : Stratified squamous epithelium
Major antibody isotype : IgG
Bukan merupakan Mucosa associated
Lymphoid Tissue
Mucus source : sel Epitel
a single layer of epithelial cells
a layer of connective tissue (the lamina
propria) and a thin muscle layer
The outside of the mucosa is lined with
mucus
Mucus- made up of high molecular mass
glycoproteins
Protecting the mucus membranes against
colonization and invasion by pathogens
Preventing uptake of foreign proteins
Preventing the harmful immune responses to
these antigens if they do reach the body interior
While systemic immunity normally functions in
sterile environment and responds strongly to
foreign invaders, MALT must economically select
nature of the response in order to avoid tissue
damage and immunological exhaustion
The first step in the induction of the mucosal immune
response is the transport of antigens across the
epithelial barrier
Besides acting as a physical barrier mucosal epithelia
provides the immune system with a continuous influx
of information about the external environment
Epithelial barrier varies from one tract to the other
single layer covers the intestinal mucosa, the
airway tract varies from pseudostratified to
simple epithelium and oral cavity, pharynx urethra
and vagina have
a multilayered squamous epithelial lining
Suatu bentuk imunitas kekebalan tubuh yang
bekerja di permukaan mukosa untuk
mencegah terbentuknya koloni bakterial
dengan komponen utama antibodi IgA.
jaringan limfoid
antibodi IgA.
secretory component
SIgA keluar dari sel epitel
Secara histologi pada usus tersusun atas sel sel
epitel (cripta) yang memiliki vili-vili untuk menyerap
makanan
diantara sel epitel terdapat dome area, yang dilapisi
epitel disebut follicle asossiated epithelium(FAE),
Sebelah bawah dari FAE ada :
- sentrum germinativum yang didalamnya
banyak terdapat sel B
- area parafolikuler banyak terdapat sel T,
dendritik dan makrofag.
Pada FAE terdapat sel M (mikrofold/membranus sell)
sebagai tempat masuknya antigen, memiliki vili
yang pendek sedikit dan jarang.
Sistem imun mukosal merupakan bagian dr
sistem imun sistemik.
Sistem imun mukosal menerima imunogen
melalui sel epitel spesifik, yaitu sel M
(microfold) atau FAE (Follicle Associated
Epithelial).
imunogen akan masuk ke sel M melalui
pinositosis atau endositosis,
Imunogen dilepas ke area sub epitelial Area
Dome di bawah epitel penutup mukosa
Area Dome di bawah epitel penutup mukosa,
mengekspresikan MHC kelas II ( makrofag, sel
dendritik, dan limfosit B)
mampu menampilkan epitop antigen untuk dikenali
limfosit T.
Folikel berisi germinal center (GC), merupakan
daerah yg didominasi limfosit B.
- GC terjadi proliferasi dan maturasi sel B.
- Di GC tidak dijumpai sel plasma yang
memproduksi IgA.
Daerah sekitar folikel dan interfolikel, banyak dijumpai
limfosit T.
limfosit yang berada di sekitar folikel dan interfolikel,
terutama merup limfosit T supresor / sitotoksik (CD8+)
Melalui Crypt
Antigen masuk ke dalam lumen melalui crypt
mampu mengenali Ag
IMUNOGLOBULIN A(IgA) Pada MUKOSA