AFINITOR 10MG | EVEROLIMUS |

MHP

Million Health Pharmaceuticals

DESCRIPTION:

 Afinitor 10mg is a derivative of Rapamycin

(sirolimus) and works similarly to Rapamycin as an
mTOR (mammalian target of rapamycin) inhibitor.

 It is normally used as an immunosuppressant to

prevent rejection of organ transplants.
In a similar fashion to other mTOR inhibitors
Everolimus' effect is solely on the mTORC1 protein
and not on the mTORC2 protein.
STAGES OF STOMACH CANCER
PRESCRIBING INFORMATION:

 Afinitor 10mg tablet are mainly indicated for the

treatment of Renal carcinoma.

 Afinitor 10mg tablets are mainly indicated for the

treatment of Breast carcinoma.

 Afinitor 10mg tablet are mainly indicated for the

treatment of Brain carcinoma.

 Afinitor 10mg is also used in various advanced

stage cancer in stomach, intestines or pancreas.
MECHANISM OF ACTION:

 Everolimus is an mTOR prohibitor, joints at high

compatibility to FK506 binding protein 12, via
producing drug complex whichinhibits the specific
of mTOR.

 This inhibitiondecreases the activity of effectors

downstream, that may cause blockage of cell
progression from G1 into S phase, subsequently
causes cell growth arrest and apoptosis
AFINITOR 10MG
PRODUCT DETAILS:

 Brand : Afinitor
Ingredients : Everolimus
Strength : 10mg
Manufactured : Novartis
Package : 10 tablets
PHARMACOKINETICS

 ABSORPTION
 The high plasma concentration time of Everolimus is 1 to 2 hours.
The effect of food with Afinitor 10mg that with heavy meal: Reduction of
systemic exposure to Afinitor 10mg tablet and the high blood plasma
concentration by 54%.

 DISTRIBUTION
Afinitor 10mg human plasma protein bound with the range of 74%.

 METABOLISM
The metabolism of Everolimus is occurred in liver, which is a substrate of
CYP3A4.

 EXCRETION
The major route of elimination;
DOSAGE MANAGEMENT

 In breast cancer, renal cell cancer, pancreatic

cancer, Neuro endocrine cancer:
The prescribed dosage is 10mg should be
taken as a single dose.
In Brain or intracranial cancer:
The prescribed dosage of Afinitor 10mg is
4.5mg/m2 orally as a single dose.
PRECAUTIONS:

Lymphomas:
 Increased exposure of skin cancers, patient
may protect from UV light
Serious infections:
 Patients receiving Afinitor 10mg have high risk
of acquiring various infections related to
bacteria, virus, and fungi. Anti-microbial agents
are preferred for the suspected patients.
Hepatic artery thrombosis:

• In liver transplant patients, Afinitor 10mg therapy

should not be recommended.
Nephrotoxicity:

• Renal function should be monitored frequently;

caution should be taken while usingAfinitor
10mg in renal impaired patients.
Angioedema:

• This may have occurred in the patients receiving

concomitantly Afinitor 10mg tablet with
Angiotensin converting enzyme agents
SIDE EFFECTS:

• Hypersensitivity reactions
• Lymphomas & other malignancy
• Serious infections
• Kidney graft thrombosis
• Hepatic artery thrombosis
• Nephrotoxicity
• Hyperlipemia
• Angioedema
• Interstitial lung disease
• Thrombocytopenia
• Male infertility
• Proteinuria
• New commencement of diabetes .
DRUG INTERACTION

• Afinitor 10mg interaction with strong inhibitor of

CYP3A4, or P-gp, leads to cause decreasing the efflux of
Everolimus and increase the plasma concentration of
Everolimus.
• Combination of Afinitor 10mg with verapamil leads to
increasing the plasma concentration of Everolimus.
• Combination of Afinitor 10mg tablet with Atorvastatin or
pravastatin causes rhabdomyolysis, due to increasing
concentration of lipid lowering agents.
• Afinitor 10mg combination with strong CYP3A4 inducers,
causes increasing the exposure of Everolimus.
CONTRAINDICATIONS:

 Some anaphylactic reaction occurs, if patients

are contraindicated to the components present
in the Afinitor 10mg tablets
PREGNANCY:

 Pregnancy category C Afinitor 10mg is needed

only by the patients after knowing the benefits
to the mother outweighs the risk to fetus.
STORAGE :

 Afinitor 10mg tablet should be kept at 25°C

Keep the tablet away from moisture, heat and
light
Dispense only in original container.
MISSED DOSE:

 If patient failed to take a single dose, patients

must consult with medical practitioner and
follow the instructions given by them.
Or the missed dose should be avoiding and
follow the regular dosing schedule.
OVERDOSAGE:

 The over dosage of Everolimus is rarely occur,

in case of over dosage patient must be provide
with supportive measures. The acute toxicity of
Everolimus over dosage should be monitored.
CONTACT US:

 PHONE NO:+91-9940472902
 EMAIL:millionhealthpharmaceuticals@gmail.com

 WEBSITEURL:https://millionpharma.com/afinitor-
10-mg.php