PYODERMA GANGRENOSUM

By :
Ni Made Wiwiet Novita Anggreni
1670121062
SGD 7
Semester VI
TITLE OF JOURNAL
 CONTENT

• ABSTRACT
• INTRODUCTION
• METHOD
• ETIOLOGY
• CLINICAL FEATURED
• DIAGNOSIS
• TREATMENT
ABSTRAK
Pyoderma gangrenosum (PG) is an uncommon, distinctive cutaneous
ulceration which is usually idiopathic, but may be associated with many
systemic disorders. The etipathogenesis of PG is still not well understood.
Clinically it is classified into ulcerative, pustular, bullous and vegetative
types. The diagnosis mainly depends on the recognition of evolving clinical
features. The treatment mainly consists of corticosteroids and
immunosuppressive agents.

INTRODUCTION
Pyoderma gangrenosum (PG) is a rare, chronic neutrophilic dermatosis of
unknown etiology. Characterized by extremely painful nodules and pustules,
which evolve into ulcers with a raised, tender and undermined border. The
cutaneous lesions might be the only manifestation of the disease, but in most
cases of cases, PG is associated to a systemic disease.
 METHOD

Retrospectively. 23 patients who were admitted and treated for PG were identified from
Western Hospital Health Information Service (medical records over a 10-year period from
July 2003 to September 2013). Were reviewed data extracted:
Age, admission for PG, sex, clinical variant of PG, site of ulcer, associate systemic diseases,
investigation results, treatment, deaths, and recurrence during follow-up.
ETIOLOGY CLINICAL FEATURED
•Understood CLASSIC FORM
•Systemic diseases 4 MAJOR  BULLOUS FORM
•Characterized by PUSTULAR FORM
immunological Alterations VEGETATIVE FORM
•Chemotactic defects and
hyperactivity of neutrophils
 DIAGNOSIS
• Patient’s history
• Physical examination
(feature of skin lession/4
major)
• Biopsy
• CBC (Complete Blood
Count)
• ANA
• X-ray
TREATMENT
 REFERENCE
Mingwei Joel Yean, Joshua Mingsheng Ye. 2014. Pyoderma Gangrenosum: A Review of Clinical
Features and Outcomes of 23 Cases Requiring Inpatient Management. Department of
Dermatology,Wes. tern Hospital, Footscray, VIC 3011, Australia, Department of Medicine,
Dentistry and Health Sciences, University of Melbourne, Parkville, VIC 3010, Australia.
September 24, 2014.

E. Cozzani, G. Gasparini, A. Parodi. 2014. Pyoderma gangrenosum: a systematic review.

Di.S.Sal., Section of Dermatology IRCCS Azienda Ospedaliera Universitaria San Martino IST
Genoa, Genoa, Italy. October 2014.

Ramesh M. Bhat. 2016. Pyoderma gangrenosum: An update. Department of Dermatology,

Venereology and Leprosy, Fr Muller Medical College, Kankanady, Mangalore, India. September
2016.

Eran Shavit, MD, Afsaneh Alavi, MD, MSc, FRCPC, R. Gary Sibbald, MD, DSc (Hons), MEd, BSc,
FRCPC (Med)(Derm), FAAD, MAPWCA. 2017. Pyoderma Gangrenosum: A Critical
Appraisal. Dermatologist, Clinical Fellow & Division of Dermatology, Department of Medicine &
Women_s College Hospital, University of Toronto & Toronto, Ontario, Canada. December 2017