CORTICOSTERIODS
Anti-inflammatory
Marielle A. Ocampo BSN 2-3
ANTIGOUT
Anti-inflammatory
GOUT
An inflammatory disorder that results in acute joint pain
and is associated with impaired uric acid metabolism.
Hyperuricemia, which can be a result of increased serum
uric acid levels or impaired uric acid excretion.
Nonsteroidal anti-inflammatory drugs (NSAIDs) and
glucocorticoids may also be used to treat gout.
Colchincine
• Is neither analgesic nor anti – inflammatory, but it suppress gouty
inflammation.
• It does NOT inhibit the synthesis or promote the excretion of uric acid, and
has no effect on blood uric acid levels.
PHARMACOKI
NETICS
• Absorbed readily after oral administration and reaches peak plasma levels
within 2 hours.
• Metabolites are excreted in the intestinal tract and urine.
Colchincine
PHARMACOdyn
amics
• Colchicine dramatically relieves the pain and inflammation of gouty arthritis in 12–
24 hours without altering the metabolism or excretion of urates and without other
analgesic effects.
• MOA :
It is thought that colchicine somehow prevents the release of the chemotactic
factors and/or inflammatory cytokines from the neutrophils, and this in turn
decreases the attraction of more neutrophils into the affected area.
Colchicine renders cell membranes more rigid and decreases the secretion
of chemotactic factors by activated neutrophils
Colchincine
PHARMACOdyn
amics
Colchicine produces its anti-inflammatory effects by binding to the
intracellular protein tubulin, thereby preventing its polymerization into
microtubules (arresting neutrophil motility) and leading to the inhibition of
leukocyte migration and phagocytosis.
It also inhibits the formation of leukotriene B4.
Several of colchicine's adverse effects are produced by its inhibition of
tubulin polymerization and cell mitosis.
Colchincine
INDICATIONS
Adverse Effects :
o Diarrhea , nausea, vomiting, and abdominal pain
o Rarely cause hair loss and bone marrow depression as well as
peripheral neuritis and myopathy.
Acute Intoxication: burning throat pain, bloody diarrhea, hematuria, and
oliguria. Fatal ascending central nervous system depression has been
reported.
Treatment is supportive.
Allopurinol (Zyloprim)
Drug Action:
Inhibits uric acid production and lowers serum uric acid levels.
Drug Use:
Used orally to treat chronic gout, and orally or IV to treat secondary
hyperuricemia related to malignancies
Adverse effect and side effects:
• CNS: Occasional drowsiness, headache
• Derm: Hypersensitivity, rash, fever, exfoliative dermatitis
• GI: Nausea, vomiting, diarrhea, and hepatitis
• Hematologic: Blood dyscrasias
Probenecid (Benemid)
Drug Action:
Increases the excretion of uric acid in urine. (URICOSURICS)
Drug use:
Used orally in prophylaxis of gout attacks. Can worsen an acute gout attack
and should not be given until the attack subsides. Also used to prolong
effects of penicillin and related anti-infectives.
Adverse effect and side effects:
• CNS: Headache
• Derm: Rash
• Hematologic: Aplastic anemia
Sulfinpyrazone (Anturane)
Drug
Action:
Increases the excretion of uric acid in urine.
Drug use:
Used orally to treat chronic gout. Also used to inhibit platelet aggregation
Adverse effect and side effects:
• CNS: Dizziness
• Derm: Rash
• GI: Effect most common and may include nausea, vomiting, abdominal pain,
GI bleeding, and hepatic necrosis
• Hematologic: Rare agranulocytosis
