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CASP Tools
• CASP Tools have been developed to help us
appraise:
• Systematic Reviews
• RCTs
• Case-control studies
• Cohort Studies
• Tools for other types of study (e.g. qualitative
research, economic evaluations and diagnostic
studies) are also available
RCTs (continued)
Appraising RCTs
Three broad issues should be considered when
examining a report of an RCT:
• Validity
• Results
• Relevance
• The CASP tool prompts us to ask questions
which will assess each of these issues in more
detail
Validity
When assessing validity the methods used in the study are
appraised
If the research methods are flawed then this may invalidate the
results of the trial
To critically appraise the methodology of an RCT you will look at
sample size, randomisation and baseline characteristics,
blinding, follow-up, data collection and interventions. These
elements are dealt with by questions 3-7 in the CASP tool for
RCTs
Also consider:
• If tests or measurement s were used were they conducted
by appropriate personnel and established tests were used?
• Were assessments frequent enough to show a pattern of
response?
• Is the duration of the study sufficient?
Results
The results of a RCT should be scrutinised in a similar way to
the method
Broad considerations are:
• What are the results?
• How are the results presented?
• How precise are the results?
This is dealt with by questions 8 and 9 in the CASP RCT tool
Presentation of Results
(Q8 in CASP tool)
Precision of Results
(Q9 in CASP tool)
P-values
Statistics Used
There should be adequate statistical analysis of the
relevant results and the statistical analysis used
should be appropriate to trial size and design
Statistical tests used should be adequately described
and referenced
Consider whether a statistician is listed as one of the
authors
Relevance
If the methodology and results are acceptable then the
applicability of the results to the local population should be
considered
Some broad issues include:
• Relevance to the local population
• Were the outcomes considered clinically important?
• Risk versus benefit of treatment
Q10 in the CASP tool prompts us to consider the issues around
the relevance of our study to our local population
Importance of outcomes
Were all clinically important outcomes considered? A single RCT
is unlikely to address all the clinically important outcomes but
consider if the original question has been answered and if any
other important outcomes have been missed out.
Other Considerations
Sub-group analysis
Remember!
Healthcare decisions are not usually made on
the basis of one trial. Other factors and other
evidence may also have to be considered
when making a decision
Systematic Reviews
Systematic reviews seek to bring the same level of rigour
to reviewing research evidence as should be used in
producing research evidence. They:
• Identify relevant published and non-published evidence
• Select studies for inclusion and assess the quality of
each
• Present a summary of the findings with due
consideration
Observational Studies
Includes cohort studies, case-control studies and cross-
sectional studies
These studies lack the controlled design of RCTs and the
evidence which comes from this type of study is therefore
considered less robust
In some cases observational studies provide the only
evidence available (e.g. emerging safety issues) and
therefore it is also important that we are able to critically
appraise these
Over to you……
Now use what you have learned from this
presentation and the tools available online to
critically appraise a randomised controlled trial
and a cohort study