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A.Tamayo U of M
Transient Ischemic
Attack
From Definition to Treatment
Arturo Tamayo MD, FAHA
Assistant Professor of Neurology U of M
Director of the Stroke Prevention Clinics
BRHA and WHSC
Disclosures
• Research board member and lecturer to
the Heart and Stroke Foundation of
Canada.
• Member of the Steering Committee of the
Canadian Stroke Strategy and Consortium
• Speakers Honoraria: Pfizer, Allergan, and
Schering-Plough
• NO STOCKS in pharmaceutical industry
A.Tamayo U of M
TIA… The Problem
• TIA and its
implications has
evolved over the last
decade implicating:
a) Definition
b) Risk stratification
c) Acute decision
making-management
d) Prognosis
A.Tamayo U of M
What is the definition of TIA?
a) Transient deficit lasting less than 24 hrs.
b) Deficit which improves (but not resolves)
within 24 hours.
c) Transient deficit lasting less than 30 min.
d) Transient deficit lasting up to an hour.
e) All of the above
TIA: Definition
• TIA was defined as an episode of focal,
transient neurological deficit of vascular
etiology that resolve in less than 24 hrs.
NINDS classification of CVD. Stroke 1990; 21:637.
•A.Tamayo U of M
TIA: Definition
•A.Tamayo U of M
TIA
The Incidence and Prevalence
•A.Tamayo U of M
• NSA sponsored telephone survey
• A total of 175,000 phone calls
• Only 8.6% was able to identify symptoms
• 10,112 participants:
2.3% (95% CI, 2.0-2.6%) had Dx of TIA
given by a physician
only 64% saw a physician within 24 hrs.
2.3% were diagnosed as Stroke.
19 of them had a previous TIA.
3.2% had a TIA but were not seen by a
doctor
Univariate analysis:
History of TIA was more common in the
elderly
Those with lower income
Fewer years of education
Neurology.2003;60:1429-34
•A.Tamayo U of M
• That is: In 2002: 204,000 TIAs in USA
• Stroke. 2005;36:720-723.
•A.Tamayo U of M
NEW DEFINITION
TRANSIENT ISCHEMIC ATTACK
•A.Tamayo U of M
TIA old vs. new definition
• Time Based • Tissue Based
• Deficit < 24 hours. • <1 hr event without
evidence of infarction.
• Suggests Benign • Indicates potential
ischemic danger.
• Delays Intervention • Encourage IMAGING and
intervention
• Inaccurately predicts • Good ischemic predictor
ischemia.
•A.Tamayo U of M
• Stroke 1999;30:1174
•A.Tamayo U of M
TIA… The Problem
• TIA and its
implications has
evolved over the last
decade implicating:
a) Definition
b) Risk stratification
c) Acute decision
making-management
d) Prognosis
•A.Tamayo U of M
Which one of the following is true?
a) TIA patients are on higher risk of stroke
within 3 months
b) Most of patient with TIA present with a
stroke within a week of first event
c) The risk differs if they have hemispheric
or retinal symptoms
d) They are on high risk of cardiovascular
problems
e) All of the above
Stroke Risk after a TIA
Study N Stroke Risk
•A.Tamayo U of M
The Northern California TIA Study
JAMA.2000:13;284(22):2901-6
• Settings
•A.Tamayo U of M
The Cohort
JAMA 2000:13;284:2901-6
• N= 1707 patients.
Mean 72 yo.
53% females.
Median spell 70 min.
• 3 months risk of stroke…… 10.5%
1 week risk of stroke ……... 6.0%
• Recurrent TIA……………… 13.2%
• Cardiovascular hospitaliz… 2.7%
• Death……………………….. 2.6%
• Any of these events………. 26.2%
A.Tamayo U of M
Higher risk of stroke within 7 days
Kaplan-Meier Survival-Free from Stroke
Patients Presenting with TIA in Emergency Room (N=1707)
10.5%
JAMA 2000;284:2901-2906
A.Tamayo U of M
What did we learn from NASCET and TIA?
Eliasziw M. et al. CMAJ 2004;30:170(7)1105-9
A.Tamayo U of M
TIA STRATIFICATION
The California TIA RISK SCALE
• Age > 60
• DM
• Unilateral weakness
• Speech impairment
A.Tamayo U of M
The California Score
A.Tamayo U of M
Risk Stratification with ABCD2
Age 1 point if > 60 years
Blood pressure 1 point if sBP >140 or dBP >90
Clinical 2 points for unilateral weakness;
features 1 point speech deficit without
weakness
Duration 2 points if >60 min; 1 point if
>10-59 min
Diabetes 1 point
*2-day stroke risk: 1%(0-3 points), 4% (4-5 points), 8% (6-7
points)
*90 day stroke risk up to 25%
Lancet 2007; 369:283-92
A.Tamayo U of M
Defining high risk.
ABCD2 + MRI (DWI / intracranial vessel occlusions)
A.Tamayo U of M
TIA- is an emergency!
WHEN SHOULD WE TREAT?
A.Tamayo U of M
ER ASSESSMENT
• Points to remember:
• ABCD2 score has a sensibility of 80%,
that is, there are 20% of patients that can
be missed.
• This scale was not include patients on
Atrial Fibrillation who are on extreme risk!
A.Tamayo U of M
3-Month Stroke Risk
According to Etiological subtype
A.Tamayo U of M
TCD and Carotid Microemboli
A.Tamayo U of M
ANTIPLATELETS
A.Tamayo U of M
PLAVIX LOADING DOSE
225-300 mg
• Rationale
NOT PROVEN EXPERIENCE IN STROKE
PATIENTS. ONE TRIAL ON ITS WAY. However:
a) Acute coronary syndromes: Dosages between
200-300mg inhibit in 15 minutes sCD 40 ligand
(sCD40L) and CRP (?).
b) Better outcome.
Am Heart J. 2006; 151(2):521 e1-e4.
Cure Study. Am Heart J. 2005;150(6) 1177-85.
Circulation 2005.112(19):2946-2950.
A.Tamayo U of M
A.Tamayo U of M
Timing of Surgical Intervention
The NASCET and ECST Studies
40 NNT=3
70 to 99% stenosis
30.2 50 to 69% stenosis
30
0
-2.9
A.Tamayo U of M
CREST TRIAL= CAE
A.Tamayo U of M
Atrial Fibrillation
• One of the strongest known
independent risk factor for
ischemic stroke.
•Chest.2004;126:429S-456S. A.Tamayo U of M
Warfarin vs No treatment
• Primary Prevention • Secondary Prevention
• Five major primary • Secondary stroke
prevention trials prevention RRR by
consistently showed: 66% (12% risk in
a) RRR 68% per year. untreated vs 4%
b) NNT 32 treated).
c) Reduced combined • NNT 13
outcome by 48% • No hemorrhagic
(stroke, systemic differences among
embolism or death) groups
• Ezekowitz MD. N Engl J
Med.1992;327:1406-1412 • EAFT Study. Lancet.
1993;342:1255-1262
A.Tamayo U of M
Hylek EM. N Engl J Med. 2003;349:1019-1026.
A.Tamayo U of M
Stroke or systemic embolism (SSE)
Noninferiority Superiority
p-value p-value
Dabigatran 110 mg
vs. warfarin
<0.001 0.34
Dabigatran 150 mg
vs. warfarin
Margin = 1.46
<0.001 <0.001
• Contributes to
Large vessel disease
Small vessel (lacunar)
LV dysfunction
• CHEP:
• <140/90 (in DM <130/80)
Stroke. 2006;37:577-617
A.Tamayo U of M
Vascular Risks
• Diabetes: Increases x 2 the risk of Stroke.
Highly correlated with HTN, and metabolic
syndrome.
Treatment reduces microvascular
complications>macrovascular.
• Cholesterol: Doubles the risk of stroke.
Risk for CAD. SPARCL (NNT = 50)
A.Tamayo U of M
TIA… The Problem
• TIA and its
implications has
evolved over the last
decade implicating:
a) Definition
b) Risk stratification
c) Acute decision
making-management
d) Prognosis
A.Tamayo U of M
EXPRESS Study
Rothwell et al. Lancet 2007
• Phase 1 vs. 2
• 90 days stroke risk
from 10% to 2%
• Medications started
right away
• Carotid
endarterectomy
expedited
A. Tamayo U of M
RECOMMENDATIONS
IN THE ER: The Never and Ifs’ rules
• NEVER FORGET THE TIA CANADIAN GUIDELINES
• Play SAFE! (never play un-safe)
• Never discharge If not sure; consult Neurologist on Call!
• Never discharge a patient unless mayor risk factors and
images have been done.
(managing hypertension, hyperglycemia, electrolytes
imbalance) and CT of brain and carotid images are
available. If severe stenosis consult neurology.
• Never discharge a patient with crescendo TIAs
• Never discharge a patient with mild deficits (that is a
stroke)
• Never discharge a patient on Atrial Fib.
A.Tamayo U of M
My Recommendations in ER (2)
• If ABCD2 score is 0-3 points and patient is
stable; REFERRAL TO STROKE CLINIC
(all patients should be seen within 3 days)
• If ABCD2 score is 4-5; patient should be seen in
ER by Neurology.
• If large or small vessel disease is suspected:
load patient with Clopidogrel (75mg x 3).
• If Patient is on Atrial Fibrillation: Patient should
be admitted on IV heparin and a
transesophageal echo should be requested to
rule out: Atrial appendage thrombus
A.Tamayo U of M
Current Research
• A) TIA Hotline
• B) Triage TIA scale
Project designer:
Susan Alcock RN
(WRHA)
Brandon-Winnipeg
Stroke Clinic Team
MANITOBA STROKE
PREVENTION CLINICS
• Brandon Regional Health Centre
Tel: 578 - 2165 Fax: 578 - 4956
• Steinbach Regional Health Centre
Tel: 320 - 4177 Fax:320 - 4171
• Winnipeg Health Sciences Centre
Tel: 787-1121 Fax: 787- 3803
• Winnipeg St. Boniface Health Centre
Tel: 235 – 330 Fax: 233 - 3285
A.Tamayo U of M
Any Questions?
• Thank you!