PROGNOSIS (PERCENTAGE OF CHILD GETTING

MENTAL ILLNESS)
RAJHMUNIRAN KANDASAMY
GENETICS IN PSYCHIATRIC ILLNESS

1.Family study
2.Twin study
3.Adoptive study
GENES INCREASES THE RISK BUT NOT CAUSE THE DISORDER
EVIDENCE BASED MEDICINE

 The mode of inheritance of bipolar affective disorder (BPAD)

appears complex, and non-Mendelian models of inheritance have
been postulated. Two non-Mendelian phenomena, genomic
imprinting and mitochondrial inheritance, may contribute to the
complex inheritance pattern seen in BPAD.
 Both imprinting and mitochondrial inheritance share the feature of
differential expression of the phenotype, depending on the parent
of origin.
WHAT IS IT
GENOMIC IMPRINTING
 Imprinting has been linked to methylation of disease
alleles during meiosis, leading to deactivation or
reduced expression of the gene products on the
offspring, but may also depend on other mechanisms.
 Is not demonstrated in BPAD but has been
proposed as a potential factor in inheritance.
MITOCHONDRIAL INHERITANCE
 Transmission of traits determined by the mtDNA
which is transmitted exclusively by mothers.
 This can be explained due to paternal mitochondria
is actively decomposed when the sperm fused with
the oocyte.