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Sheila Kori
NF1
Most common neurocutaneous disorder, autosomal dominant
Incidence: 1: 3,000-5,000
NF1
Best Imaging Tool: MRI to evaluate for white matter lesions, visual pathway
gliomas, and plexiform lesions
Imaging Findings:
Hyperintense lesions on T2W1
White Matter lesions involve dentate nuclei of cerebellum, globus
pallidus, thalamus, pons, midbrain, hippocampus
Visual pathway gliomas
Sphenoid wing dysplasia
Aneurysms and moyamoya
NF2
“MISME”: Multiple intracranial schwannomas, meningiomas,
ependymomas
Incidence: 1: 40,000
NF2
Imaging Findings:
Bilateral vestibular schwannomas
Characteristics on MRI
Well defined margins
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patients with neurofibromatosis 2: MR imaging findings and correlation with genotype.
Radiology 2001; 218:434
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1992; 13:1071-1077
5. Koeller K,Rosenblum, SR, Morrison AL. Neoplasms of the Spinal Cord and Filum Terminale:
Radiologic-Pathologic Correlation. RadioGraphics 2000; 20:1721–1749