Test Bank

NCM 106- Pharmacology

1. Distribution of drugs to specific tissues
(a) Is independent of blood flow to the organ
(b) Is independent of the solubility of the drug in
that tissue
(c) Depends on the unbound drug concentration
gradient between blood and tissue
(d) Is increased for drugs that are strongly bound to
plasma proteins
(e) Has no effect on the half-life of the drug
2. Regarding termination of drug action
(a) Drug must be exerted from the body to
terminate their action
(b) Metabolism of drugs always increases their
water solubility
(c) Metabolism of drugs always abolishes their
pharmacologic activity
(d) Hepatic metabolism and renal excretion are the
two most important mechanisms involved
3. The following are excreted faster
in basic urine
(a) Weak acids
(b) Strong acids
(c) Weak Bases
(d) None of the above
4. The route of drug administration that gives
the most rapid onset of the pharmacological
effect is
(a) Intramuscular injection
(b) Intravenous injection
(c) Intradermal injection
(d) Subcutaneous injection
5. A drug that binds to a cell receptor
and causes a response is called an
(a) Agonist
(b) Antagonist
(c) Receptor blocker
6. Pharmacodynamics considers:
(a) The way in which the body affects the
drug
(b) The effects of the drug on the body
and the mode of drug action
(c) Drug metabolism
7. When a drug has a low therapeutic
index, that drug should be
(a) Used mostly orally
(b) Used mostly intravenously
(c) Considered a potentially toxic
substance
(d) Given only in submilligram doses
8. A desired clinical response may be delayed
altered or blocked by:
(a) A drug that does not go into solution
(b) A drug that does not get to its site of action
(c) Lack of absorption from site of administration
(d) All the above
9. Factor which can effect the
absorption of drug is
(a) Dissolution rate
(b) Particle Size
(c) Lipid Solubility
(d) All the above
(e) None of the above
10. Bio-transformation of the drugs is
to render them
(a) Less lipid soluble
(b) More protein bound
(c) Less ionized
(d) Less protein bound
11. A ‘toxic effect’ differs from a ‘side
effect’ in that
(a) It is not a pharmacological effect of the
drug (b) It is a more intense
pharmacological effect that occurs at high
dose or after prolonged medication
(c) It must involve drug induced cellular
injury (d) It involves host defence
mechanisms
12. Tachyphylaxis is
(a) A drug interaction between two similar
types of drugs
(b) Rapidly developing tolerance
(c) A synergism between two types of
drugs
(d) None of the above
13. Advantage of sublingual route
include the following except
(a) It has a rapid onset of action
(b) Spitting out the tablet can terminate its
action
(c) Its usefulness is limited to treat local
conditions
(d) It avoids first pass hepatic metabolism
14. The therapeutic index of a drug is
a measure of its
(a) Safety
(b) Potency
(c) Efficacy
(d) Dose variability
 15. High plasma protein binding
(a) Increases the volume of distribution of
the
drug
(b) Facilitates glomerular filtration of the
drug
(c) Minimizes drug interactions
(d) Generally makes the drug long acting
1. 22 kg = ____lbs
2. 15000 mcg= ____mg
3. 2000 ml = ____L
4. 5 ft = ____cm
5. 2.5 g =____mg
6. 2 lb =____oz
7. 1oz =____Tbsp
8. 2 gr =____mg
9. 3 tsp =____Tbsp
10. 1800 g =____kg
Order: Ranitidine 300mg tab PO q8
Stock: Ranitidine 150mg/tab
1. How many tablets will you give per
dose?
2. Total tablets per day?
3. Total dosage per day.
 What volume is required for an injection
if 600mg are ordered and stock ampules
contain 350mg/ml?

 What volume is required for an injection

if 750mg are ordered and stock ampules
contain 200mg/ml?
 A 3800g infant has been ordered for a
medication for 0.6mg/kg/day over 6 doses
per day. How much will you give the
patient per day?

 A patient needs 1g of a medication. The

Drug Handbook states that each gram of
this medication is to be mixed with 10mL
of water over 3-5 minutes via IV bolus.
After preparing the medication, how many
mL per minute would you administer if
you do it over 3 minutes ?
A patient weighs 40kg and is prescribed
a medication for 0.4mg/kg/dose. The
stock available is 20mg/5mL. What
volume will you give to the patient?

A child weighs 13.5kg and is prescribed

a medication for 0.8mg/kg/dose. The
stock strength is 10mg/2mL. What
volume will you give to the patient?
 How many mg per mL will be infused for
a solution of 350mg of a medication in
100mL of saline?
 A patient needs 3g of a medication that
comes in 15mg/mL. How much of the
solution will be given?
A patient weighs 6.5kg and is prescribed
a medication with a dose of
0.5mg/kg/day in equal doses every 12
hours. How many mg will you give per
dose?
 At the end of your shift, your patient
had a 3 cups of water and a 500ml of
bottled juice. His diaper weighed
0.75kg.
 How many ml is your total oral fluid Intake
 How many ml is your total urine output
 The volume of an IV drip to be
administered is 0.25L over 8 hours. The
drop factor is 60. How many drops per
minute will it be
 The dose to be given of a medication is
1.2g. The stock strength is 2g/10mL.
Calculate the mL needed to deliver the
medication.
 The dose to be given of a medication is
5mg. The stock strength is 1mg/4mL.
Calculate the mL needed to deliver the
medication.
 The doctor orders 80 mg of liquid cough
syrup. The cough syrup is labeled
100 mg in 5 ml. How many ml should the
patient receive?
 DESIRED: 125 mg per kg body
weight
 AVAILABLE: 0.25 g per cc
 BODY WEIGHT: 22 lbs
 GIVE: _______________ cc
A child weighs 25kg and is ordered
12mg/kg/day q6, stocked as 40mg/4ml.
Find the mg per dose, the equivalent
mls and the total dose over 24hrs to be
given.