SIFAT-SIFAT SITOKIN

• SEL PENGHASIL
• SATU JENIS SITOKIN DAPAT DIHASILKAN OLEH LEBIH DARI
SATU JENIS SEL
• FUNGSI
• LEBIH DARI SATU FUNGSI YANG BERTUMPANG TINDIH
DENGAN FUNGSI SITOKIN JENIS LAIN
• MEMPUNYAI LEBIH DARI SATU JENIS SEL SASARAN
• MEKANISME KERJA
• MEMPUNYAI EFEK SETELAH BERIKATAN PADA RESEPTOR SEL
SASARAN

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 KLASIFIKASI

• BERDASARKAN SEL PENGHASIL UTAMA:

• MONOSIT: MONOKIN
• LIMFOSIT: LIMFOKIN (LIMFOSIT TH)
• BERDASARKAN FUNGSI:
• INTERLEUKIN (IL)
• COLONY STIMULATING FACTOR (CSF)
• INTERFERON
• CHEMOKINE
• KELUARGA TNF
• GROWTH FACTOR (GF)

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 MONOKIN

• SEL PENGHASIL
• MONOSIT
• ANGGOTA
IL-1
TNF
IFN-
IL-6

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 MONOKIN

IL-1 IL-8 TNF- IL-6 IL-12

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KASKADE MONOKIN SETELAH INDUKSI LPS

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 KASKADE SITOKIN SETELAH MENDAPAT
TANTANGAN LPS/TNF (DALAM SEPSIS)

LPS TNF

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EFEK IL-1 DAN TNF

SEL-SEL IMUN

SEL-SEL NON-IMUN

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EFEK SITOKIN YANG DIHASILKAN LIMFOSIT T

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NOMENKLATUR DAN FUNGSI SITOKIN YANG DIHASILKAN LIMFOSIT

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FUNGSI SITOKIN DALAM PENDEWASAAN SEL-SEL DARAH

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 CHEMOKINE

Chemokines are secreted basic protein of 8-10 kd that represent

the largest family of cytokines encoded in the human genome
with close to 50 members 3). Chemokines appear to have two
main functions in regulating allergic inflammation : leukocyte
trafficking and leukocyte activation. Members of the
chemokine family fall into three broad groups: a) CC
chemokines with two adjacent cysteines, b) CXC chemokines,
in which the same two adjacent cysteine residues are separated
by another amino acid, and c) C chemokines, where only one
cysteine residue is present at the same site as in other
chemokines.

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 FUNGSI CHEMOKINE

The three groups of chemokines act on

different cell types :
 in general, the CXC chemokines promote
migration of neutrophils;
 while the CC chemokines promote the
migration of monocytes;
 the C chemokine that have individual
specialized functions.
 A subset of chemokines has been found to be
upregulated in allergic diseases.

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 SIFAT-SIFAT CHEMOKIN

CHEMOKINE IL-8 PBP/- MP-1 MCP-1 RANTES Lymphotactin Eotaxin

TG/NAP or MCAF

SUBCLASS CXC CXC CC CC CC C C

Chemoattra Chemoattra Chemoattract Chemoattra Chemoattractant

E T ctant to ctant for ant to ctant for for pre-T cells to
F CELLS naïve T CD8 T cells memory T CD4 T cells thymus
F cells cells
E Chemoattract Chemoattractant
C MONO ant
T CYTES Activation

O
Chemoattra Chemoattra Eosinophils
N
NEU- ctant ctant chemoattractant
TRO- Activation Induction Eosinophhils
PHILS of activation
degranulati
on

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 INTERFERON (IFN)
• AWAL PENEMUAN
• Isaacs dan Lindenmann tahun 1957
• FUNGSI
• EFEKTOR
• TERUTAMA ANTI VIRUS, PADA pH 2.00, NON-SPESIFIK
• ANTIPROLIFERATIF
• IMUNOMODULATOR
• SEL PENGHASIL
• SEL TERINFEKSI VIRUS (LEKOSIT, FIBROBLAS (IFN- & IFN-)
• LIMFOSIT SEBAGAI LIMFOKIN (IFN-), NK-CELL
• NOMENKLATUR
I) IFN - (20 SUBTIPE), IFN- (2 SUBTIPE), IFN- (LIMFOKIN)
II) IFN FIBROBLAS & IFN IMUN

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3 FUNGSI IFN- DAN IFN-

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MEKANISME ANTIVIRUS IFN

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RESPONS TERHADAP INFEKSI VIRUS

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INTERFERON- DIHASILKAN OLEH SEL NK KARENA INFEKSI VIRUS

TH
CD4

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 GROWTH FACTOR (GF)

NAMA KEPANJANGAN
TGF- Transforming Growth Factor-
PDGF Platelet-derived Growth Factor
EGF Epidermal Growth Factor
FGF Fibroblast Growth Factor
KTGF Keratocyte T cell Growth Factor
ENKGF Epidermal NK Cell Growth Factor

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