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Current Surgical Therapy: Evaluation of the isolated neck mass by Philip, Smith et al
History
• Age
• Personal or family history of malignancy
• Smoking/tobacco use or heavy alcohol
• Sun and radiation exposure
• Persistent mass, dysphagia, hoarseness,
neurologic deficit, epistaxis, radiating pain
• Constitutional symptoms
• Rapidly developing tender masses are often
infectious/inflammatory
• Prior treatment/surgery
Current Surgical Therapy: Evaluation of the isolated neck mass by Philip, Smith et al
Surgery At A Glance, Fifth Edition, by Pierce and Niel
Current Surgical Therapy: Evaluation of the isolated neck mass by Philip, Smith et al
Imaging
• Chest X-ray/CT thorax
• Ultrasound scan
– Hyper or hypoechogenicity, cystic degeneration, punctuate calcifications,
unclear borders with surrounding structures perinodal oedema
• CT scan
– Invasion or distortion of normal anatomy
– If thought to be nodal metastasis, can identify primary source in 20%
• MRI
– Presence of invasion into surrounding structures especially vascular or neural
structures
• PET
– Not first-line
– Metastatic squamous cell carcinoma of unknown primary
– Further workup for known diagnosis
Current Surgical Therapy: Evaluation of the isolated neck mass by Philip, Smith et al
Tissue diagnosis
• FNA
• Core biopsy
• Excision biopsy
• Panendoscopy and biopsy
– Laryngoscopy, bronchoscopy and esophagoscopy
– Biopsy
– Tonsillectomy (tonsils are found to be the primary
source in 20-40% of these patients)
Current Surgical Therapy: Evaluation of the isolated neck mass by Philip, Smith et al
Thyroid
Work-up
• Thyroid function test
• Serum Tg (not initial evaluation)
• Calcitonin (if suspect MTC)
• Ultrasound
– Ill-defined borders, microcalcifications, internal
vascularity, absence of colloid halo sign, hypoechogenicity,
suspicious lymph nodes
• FNA
• Radionuclide thyroid scan (if TSH subnormal)
• CT/MR neck/PET
• Nasopharyngolaryngoscopy
National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Thyroid Carcinoma Version
Thyroid carcinoma
• Medullary thyroid cancer
– MEN2
– Serum calcium, calcitonin, CEA, pheochromocytoma screen, RET
proto-oncogene
– Total thyroidectomy + central neck dissection ± lateral neck
dissection
– Adjuvant EBRT
• Anaplastic cancer
– 10 year <1%, poor prognosis
– FBC, calcium, TSH, CT/PET
– Local disease: total thyroidectomy and selective resection of
local/regional structures and lymph nodes
– EBRT, chemotherapy, best supportive care
National Comprehensive Cancer Network Clinical Practice Guidelines in Oncology: Thyroid Carcinoma Version
Parathyroid
Primary hyperparathyroidism
• Most common cause for hypercalcaemia
• Excessive PTH production
• Incidence 1%, 2% after age 55
• Women 2-3 times more likely
• Single adenoma in 80-85%
• Parathyroid carcinoma in 1%
• Present in nearly all patients with MEN 1 and
25% in MEN 2A