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  • The Role of Vitamin D Concerning Autoimmune

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    Nina Hasnani
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    The document discusses the role of vitamin D in autoimmune diseases. It first provides background on vitamin D as a fat-soluble vitamin and prehormone. It then discusses the prevalence of autoimmune diseases and how vitamin D status is related. The classic role of vitamin D in regulating calcium, bone, and renal function is described. Non-classic roles of vitamin D in modulating immune response and regulating other systems like skin, muscle, and nervous system are listed. Finally, the effects of the active form of vitamin D, 1,25-dihydroxy vitamin D3, on immune cells like Th1, Th2, T reg cells, and dendritic cells are summarized in a table.

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    THE ROLE OF VITAMIN D CONCERNING AUTOIMMUNE

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    The document discusses the role of vitamin D in autoimmune diseases. It first provides background on vitamin D as a fat-soluble vitamin and prehormone. It then discusses the prevalence of autoimmune diseases and how vitamin D status is related. The classic role of vitamin D in regulating calcium, bone, and renal function is described. Non-classic roles of vitamin D in modulating immune response and regulating other systems like skin, muscle, and nervous system are listed. Finally, the effects of the active form of vitamin D, 1,25-dihydroxy vitamin D3, on immune cells like Th1, Th2, T reg cells, and dendritic cells are summarized in a table.

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    © All Rights Reserved
    Download as PPTX, PDF, TXT or read online from Scribd
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    5 views28 pages

    The Role of Vitamin D Concerning Autoimmune

    Uploaded by

    Nina Hasnani
    The document discusses the role of vitamin D in autoimmune diseases. It first provides background on vitamin D as a fat-soluble vitamin and prehormone. It then discusses the prevalence of autoimmune diseases and how vitamin D status is related. The classic role of vitamin D in regulating calcium, bone, and renal function is described. Non-classic roles of vitamin D in modulating immune response and regulating other systems like skin, muscle, and nervous system are listed. Finally, the effects of the active form of vitamin D, 1,25-dihydroxy vitamin D3, on immune cells like Th1, Th2, T reg cells, and dendritic cells are summarized in a table.

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    © All Rights Reserved
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    of 28

    Literature review

    Alergy & Immunology division

    ROLE OF VITAMIN D
    TO AUTOIMMUNE
     
    Background

    Fat-soluble
    vitamin
    Vitamin D
    Pre
    hormon
    Prevalence of autoimmune and vitamin D
    status

    Prevalence
    autoimmune

    vitamin D
    status
    CLASSIC ROLE OF VITAMIN D

    renal

    intestine Vit D bone

    PTH
    • Control of central nervous system 8
    • Control of muscular function 7
    • Regulation of insulin secretion 6
    • Regulation of the renin-angiotensin system 5
    • Regulation of skin function and differentiation 4
    • Immune response modulation 3
    • Apoptosis regulation 2
    • Cell growth supression 1
    Non-classic role role of vitamin D
    autoimmune Vit D
    Table 1. 1,25-Dihydroxy Vitamin D3
    (1,25[OH]2D3)and Immunoregulation

    Cell Effect of 1,25(OH)2D3


    Th1 Decreased number
    Suppress function

    Th2 Increase number / function


    Suppress function

    T reg Increase function & number


    DC Inhibit maturation
    Inhibit Th1 induction
    Increase Th2 induction
    TERIMA KASIH

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