Department of pharmaceutical

sciences

Microencapsulation by
coacervation

Submitted by. Submitted to.

Niqash Ahmad Sir Abu Bakar Munir
Muhammad Faisal
 3

Principle

2 4

Polymer used Mechanisms

Microencapsulation by
coacervation
1 5

INTRODUCTION Applications
 Introduction

• Microencapsulation:
A technique in which polymer
Coating is applied on drug
Particles.
Coacervation is microencapsulation
By phase separation.
 Polymer used

Synthetic Semi synthetic

Natural  Methyl
cellulose
 Ethyl
 Polylactic cellulose
acid  Agar  Hydroxy
 Polyacryl  Albumin ethyl
acetate  Gelatin cellulose
 Starch  Hydroxy
 Pectin propyl
cellulose
 Classification

Organic Aqueous

complex simple

Two polymer used One polymer is used

for coating for coating.
 Principle

• Solution formation
1

• Dispersion of drug
2

• Phase of separation
3
 1

By temperature
change

By Polymer
By salt
polymer 2
5 addition
interaction

Mechanisms

By incompatible
By non solvent
polymer 3
addition
4 interaction
 By Temperature change
Steps
 Solution of polymer.
Drug  Dispersion of drug
Polymer  Phase separation due to
temperature change.
 Encapsulation.

Solvent Solution
 By Temperature change

 Decrease in
temperature.
Encapsulation
 Encapsulation
due to phase
change.

Ice bath Micro capsules

By salt addition:
Steps:
 Solution of polymer.
 Drug is suspended.
 Addition of salt drop by
drop.
 Phase separation and
encapsulation.

Solution
 By salt addition

Addition of salt
drop by drop.
Encapsulation.

Microcapsules.
 Incompatible polymer interaction

 Two polymers are used.

 One having greater
Polymer A Drug Polymer B
solubility than other.
 Encapsulation.
 By non solvent addition

1 Solution of polymer is formed

2 Drug is dispersed in polymer

solution

3 Liquid which is non solvent

for given polymer is added

4 Phase separation of polymer

5 Encapsulation of drug
 Polymer polymer interaction
 Solution of polymer.
 Dispersion of drug in polymer solution.
 Phase separation due to polymer interaction.
 Encapsulation.
Polymer A Polymer B
 Polymer polymer interaction

 Complex of polymer
encapsulate the drug.
 Microencapsules are
obtained.

Encapsulation.

Microcapsules
 Applications

Control and modified release

1 delivery system

2 Avoid deteriorating effect

3 Improve handling of
product.

4 Stability of product