SYNTHESIS AND

APPLICATION OF
MAGNETIC
NANOPARTICLE
Carbon-coated FeCo nanoparticles as sensitive magnetic-particle-
imaging tracers with photothermal and magnetothermal properties
MEDICAL IMAGING
TECHNIQUES
 Computed Tomography (CT)
 Magnetic Resonance Imaging (MRI)
 Positron Emission Tomography (PET)
 Optical imaging
 Ultrasound
 Single Photon emission computed tomography. ( SPECT)
MAGNETIC
PARTICLE
IMAGING
Magnetic particle imaging
(MPI ) use magnetic
nanoparticles which are
 Biocompatible
 Well tolerated
 And offer the potential to be
quantitatively imaged.
BASIC PRINCIPLE OF MPI
It rely on the interaction of the MNPs with
specific magnetic fields that are externally
applied because of this interaction a
characteristics particle signal can be detected
and later reconstructed to an image
represented of the particle
HIGHER SENSITIVITY
MPI MRI

It detects the change in electronic magnetization of It measures the change in nuclear magnetization of
iron. water proton

MPI detection is 22 million times greater than MRI

MPI PET

MPI tracers do not use radioactivity. PET requires the use of radioactive tracers
containing radioisotopes.
HIGH INTENSITY OF MPI
SIGNAL
 The magnetization satyrates as the magnetic field strength increases and high magnetization
saturation leads to high intensity of MPI signal.
 Among various magnetic nanoparticles, iron-cobalt FeCo nanoparticles show superior
magnetic saturation compared with other magnetic material.

Carbon – coated FeCo Carbon – coated FeCo

nanoparticles with a nanoparticles
core size of 10nm in Produces an MPI signal
diameter produced an og 14.91times greater
MPI signal of 6.08 than that of Feraheme at
times greater than that the same core molar
of Vivo Trax . concentration .
SYNTHESIS AND
CHARACTERIZATION
FeCo@C nanoparticles are prepared using methane Chemical vapour deposition (CVD)
1ST STEP:
 Iron nitrate and cobalt nitrate are loaded into fumed silica powder saturated in methanol
solution.
 The dried metal- loaded silica was heated to 800ºC in a CVD device.
 Then it is subjected to methane flow at 800ºC for carbon deposition onto the FeCo
nanoparticles.
 The resulting nanoparticles were coated with graphitic carbon shell.
COMPOSITION
CHARACTERIZATION
APPLICATION
 Nanoparticles have Photothermal and magnetothermal properties therefore they can be used
for tumour ablation in mice.
 They have high optical absorbance in a broad near infra red region.
 MPI traces are used for cell tacking, neuroimaging
 Carbon-coated FeCo nanoparticles may confer advantages in cancer imaging and
hyperthermia therapy.
MPI IMAGING OF CANCER
XENOGRAFTS IN MICE
ADVANTAGES
MPI imaging has following advantages
 For disease diagnosis
 Treatment monitoring
 Tomographic imaging capability
REFERENCE
 https://sci-hub.se/https://www.nature.com/articles/s41551-019-0506-0