Industrial Training Final Presentation on

SARTHI PHARMA-RAJKOT, GUJARAT

P r e p a re d By : I nt e r n al G ui de :
U ME SH N A RIG A RA P r of . N it in J a y ak u m ar
( 1 7S D S ME0 1 0 11 )
External Guide:
M r. C h i n t a n p a t e l &
M r. J a y m a k a d i y a

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Outline
Company Profile
Name of Department
Manufacturing of product details
HVAC
Production Process
Production Machinery
Packaging Machinery
Organization structure
conclusion

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Company Profile – SARTHI PHARMA
Company name: SARTHI PHARMA
Full Address: Rajkot Bhavnagar Highway, Near Global Institute of Ayurveda, Kasturbadham,
Rajkot, Gujarat-360020
Name of Chairman: DR. CHETAN DETROJA , MR. VISHAL MANGROLIYA , MR. UMANG
GHODASARA , DR. SAMIR ATARA.
Establishment date & year: JUNE,2019
No. of Departments: SEVEN(7)
No. of Employees (approx.): FIFTY SIX(56)
Finished product: NA
Certifications (if any): GMP

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Company Profile – SARTHI PHARMA
1. Broad Category of Plant: It is a pharmaceutical Finished formulation manufacturing unit.
2. Sub Category of Plant: Beta Lactam (Antibiotics)
3. Site area: 4800 square meter
4. Proposed annual production capacity:
1. Tablet: 1000 Million
2. Capsule: 225 Million
3. Dry Syrup: 18 Million
5. Regulatory Permissions:
1. Food and drug Control Administration, Gandhinagar, Govt of Gujarat
2. Gujarat Pollution Control Board, Gandhinagar, Govt of Gujarat

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Name of Departments
1. QA-(QUALITY ASSURANCE)
2. QC-(QUALITY CONTROL)
3. ENGINEERING
4. PRODUCTION
5. PACKAGING
6. HR-(HUMAN RESOURCES)
7. WARE HOUSE

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Manufacturing of product details(Tablet)
Sr.No Composition Dosage Form

01 Amoxycillin 125 mg Dispersible Tablet

02 Amoxycillin 250 mg Dispersible Tablet

03 Amoxycillin 200 mg+Clavulanate Potassium 28.5 mg Dispersible Tablet

04 Amoxycillin 400 mg+Clavulanate Potassium 57 mg Dispersible Tablet

05 Amoxycillin 250 mg Film Coated Tablet

06 Amoxycillin 500 mg Film Coated Tablet

07 Amoxycillin 250 mg+ clavulanate Potassium 125 mg Film Coated Tablet

08 Amoxycillin 500 mg+ clavulanate Potassium 125 mg Film Coated Tablet

09 Amoxycillin 875 mg +clavulanate Potassium 125 mg Film Coated Tablet

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Manufacturing of product details(Capsule)
Sr.No Composition Dosage Form

01 Ampicillin 250 mg Capsule

02 Ampicillin 500 mg Capsule

03 Amoxycillin 250 mg Capsule

04 Amoxycillin 500 mg Capsule

05 Amoxycillin 250 mg +Cloxacillin 250 mg Capsule

06 Cloxacillin 250 mg Capsule

07 Cloxacillin 500 mg Capsule

08 Dicloxacillin 250 mg Capsule

09 Dicloxacillin 500 mg Capsule

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Manufacturing of product details(Dry Powder)
Sr.No Composition Dosage Form

01 Ampicillin 125 mg Dry Powder Suspension

02 Ampicillin 125 mg+ Cloxacillin 125 mg Dry Powder Suspension

03 Amoxycillin 125 mg Dry Powder Suspension

04 Amoxycillin 250 mg Dry Powder Suspension

05 Amoxycillin 125 mg +Clavulanic Acid 31.25 mg Dry Powder Suspension

06 Amoxycillin 200 mg +Clavulanic Acid 28.5 mg Dry Powder Suspension

07 Amoxycillin 250 mg +Clavulanic Acid 62.5 mg Dry Powder Suspension

08 Amoxycillin 400 mg +Clavulanic Acid 57 mg Dry Powder Suspension

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

HVAC
1. Heating, Ventilation and air-conditioning(HVAC) system play an important
role in the manufacture of pharmaceutical product to prevent contamination
and to provide comfortable working conditions.
2. What is contamination ?
3. Contamination are …
1. Substance other than product manufactured
2. Foreign products
3. Particulate matter

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Importance of HVAC in pharma company
All critical processing areas in Pharmaceutical Unit like Dry Syrup
filling & sealing, Tablet Compression, Tablet inspection, Capsule
filling, blister packing, strip packing where the product is exposed to
atmosphere are kept at 25±2°C, relative humidity of not more than
55% and are designed for class 1,00,000 condition, Ancillary areas
such as quarantine, passages I, II, III and IV have 3 micron filters.

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Clean room
1. Cleanroom plays a vital role in maintenance of area condition inside the manufacturing
area.
2. Different class of area defined based on the allowed particles inside the area which is as
per below Table.
3. At Sarthi Cleanroom designed as per class 100000

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Important parameters controlled in HVAC system
1. Temperature (Heating & cooling)
2. Humidity (humidifying & dehumidifying)
3. Ventilation
4. Pressure

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Air handling unit(AHU)
1. AHU used to condition and circulate air as
part of HVAC system.
2. AHU is a large metal box containing
Primary filter, Blower, Cooling coil, Heater
and Micro filter.
3. Connects to ductwork that distributes the Add image here
conditioned air through the production
area and returns it to the AHU. (ahu)

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

De-humidifier unit (DHU)
1. DHU is quite similar to a AHU. The major
difference is that it maintains the level
humidity in the air with the help of
desiccant rotor.
2. All DHUs are designed to maintain NMT
20% RH with 10% of fresh air.
Add image here
(dhu)

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

HVAC ductwork
1. When conditioned air cannot be supplied directly from air conditioning equipment to the
space to be conditioned, then the ducts are installed.
2. Generally duct made from galvanized iron sheet.
3. Thickness of galvanized iron duct varies from 26 gauge to 16 gauge
4. Shape of air duct
1. Rectangular duct
2. Round duct
3. Flexible duct
Add image here

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

HVAC ductwork
1. A Damper is valve or plate that stops or regulates the flow or air inside a duct.
2. A Fire dampers are passive fire protection products used in HVAC to prevent the spread of
fire inside the ductwork through fire-resistance rated walls and floors.
3. Riser is also part of duct , which are used to collect the return air

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

 HVAC ductwork
1. A Diffusers are the thermal units located in each room to be provided with conditioned air. They are
placed in the center of each room for proper distribution of air to every corner
2. They are different types of diffusers as per the direction of flow like,
1. One way diffuser
2. Two way diffuser
3. Three way diffuser
4. Four way diffuser add image here
5. Circular diffuser

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

 HVAC Chiller
1. HVAC chillers are refrigeration system that provide cooling for industrial and commercial application. They use water, oils
or other fluids as refrigerant. HVAC chillers included a compressor, condenser, thermal expansion valve and evaporator.
2. Chiller can classified as:
3. Vapour compression chiller
1. Reciprocating
2. Centrifugal
3. Screw
4. Scroll
4. Vapour absorption chiller
1. Lithium bromide water
2. Ammonia water
5. Water cooled condenser
6. Air cooled condenser

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Production Process
1. Direct Compression
2. Dry Granulation
3. Wet Granulation

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Production Machinery
1. Roller Compactor
2. Octagonal Blender
3. Tablet Compression
4. Tray Dryer
5. Table Coater

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Packaging Machinery

PVC Blister packing machine

• Polyvinylidene chloride can be coated
onto a PVC film to obtain very high add image here
moisture and oxygen barrier properties
depending on the coating weight. PVDC of Pm
coated blister films are the most common
and prevailing barrier films used for
pharmaceutical blister packs.

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Packaging Machinery

Alu-Alu Blister machine 1. add image here

• There are two servo motors for
operating the Indexing and the feeding
system of the machine. The
entire machine is mounted on the six
height adjustable studs so that the
entire area below the machine is easily
sanitized. The machine will be properly
guarded to ensure operator safety.

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Packaging Machinery

Strip machine 1. add image here

• The product is fed through hopper and
feeding device flows to the heat sealing
roller cavities, the desired laminated
foil from the two rollers is drawn on the
sealing rollers which packs and seals
the products continously. The
sealed strip passes through the vertical
and horizontal cutters to get
desired strip sizes.

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Organization structure
Plant Layout

1. add image here

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Organization structure
Ground Floor

1. add image here

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Organization structure
First Floor

1. add image here

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

Conclusion
1. By this Industrial training I has learned knowledge about problem of real life
industrial project and able to work under supervisor and direction of developing
the skills.
2. In this internship I have done the practical on production and packaging machines.
3. By this internship learning about HVAC system in pharma industries.
4. During our training period, we had seen the various machines in the industry. The
highly sophisticated machines that work precisely must be operated with intense
care for optimum use. We could acquire a lot of information regarding the latest
machine and their working procedures.
 

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

References.
Web links.
1. https://sarthipharma.com
2. "HVAC". Merriam–Webster Dictionary.
3. Market Venture Philippines Inc. web site (2006-04-19). "What is a Clean Room?"
4. Understanding Cleanroom Classifications
5. III, Herbert W. Stanford (2016-04-19).
HVAC Water Chillers and Cooling Towers: Fundamentals, Application, and Operation, Secon
d Edition
. CRC Press. p. xvii. ISBN 9781439862117

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY

 Thank you..

Questions ???

DEPARTMENT OF MECHANICAL ENGINEERING, SCHOOL OF DIPLOMA STUDIES, RK UNIVERSITY