PERAN GIZI DALAM HEMATOPOIESIS

dr. Amelya Augusthina Ayusari MGizi SpGK

Laboratorium Gizi
Fakultas Kedokteran
Universitas Sebelas Maret
OVERVIEW
PROSES HEMATOPOESISIS

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HEMATOPOIETIC STEM CELLS

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Hematopoietc
stem cells
(HSCs) are
responsible for
sustaining life-
long blood
formation or
hematopoiesis

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NUTRITION FOR HEMOPOESIS

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• Dormant HSCs are thought to have low energy and
biosynthetic requirements, as compared to actively dividing
cells
• Additionally, the HSC niche within the BM is hypoxic, and is
thought to limit oxidative phosphorylation (aerobic
respiration).
• Hypoxia and associated hypoxia-inducible factor (HIF)
activity are thought to play an important role in maintenance
of HSC self-renewal
• HSCs are therefore thought to heavily rely on anaerobic
respiration, and genetic inhibition of glycolysis has been
shown to inhibit HSC maintenance
• By contrast, proliferation is linked to oxidative
phosphorylation
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NUTRITION FOR HEMOPOESIS

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� HSCs have also recently been found to exhibit low rates of protein
translation, suggesting a lower requirement for amino acids than
other proliferative cell types for protein synthesis
� HSC maintenance was dependent on the amino acid valine
� Ex vivo HSC proliferation was also dependent on valine as well as
cysteine.
� By contrast, reducing threonine improved ex vivo HSC
maintenance, suggesting threonine (or downstream metabolites)
could be playing a role negative role in HSC function.
� Cysteine was found to play an important role in biosynthesis of the
antioxidant glutathione the metabolic roles for valine and threonine
remain an open question.
� Glutamine was shown to regulate HSC commitment into erythroid
differentiation where it appears to play an important role in de
novo nucleotide biosynthesis.
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ASAM AMINO ESENSIAL

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Perbedaan asam amino esensial dan non esensial, dimana
Asam amino esensial adalah asam amino yang tidak dapat
diproduksi oleh tubuh sedangkan asam amino non esensial
adalah asam amino yang dapat diproduksi tubuh dengan
sendiri.

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 NUTRITION FOR HEMOPOESIS

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� Vitamins are essential nutrients necessary for human
health.
� Roles for vitamins A, C, and D in HSC maintenance
have been recently been identified
� vitamin A (and its oxidation-derivative retinol) regulated
HSC dormancy.
� In mice, a vitamin A-free diet caused loss of HSCs
following stress activation, by inhibiting the re-entry of
HSCs into dormancy
� Vitamin D was recently shown to regulate HSC
proliferation and self-renewal
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� VC has been found to promote the development of T cells from
murine5 and human hematopoietic progenitor cells.
� VC at high concentrations reduces the viability of lymphocytes and
inhibits lymphocyte proliferation in vitro
� While optimal concentrations of VC promote B-cell proliferation
in response to LPS8 and T-cell proliferation
� By contrast, depletion of vitamin C in mice was shown to increase
HSC frequency and function [Vitamin C is a co-factor for the
enzymatic activity of the TET family of DNA hydroxylases, of
which TET2 is a well-described negative regulator of HSC self-
renewal Vitamin C is thought to act via TET2-dependent and
independent pathways to limit self-renewal As discussed below,
vitamin C was also found to regulate leukemogenesis.
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IMMUNE SYSTEM

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1. Innate immunity
2. Adaptive immunity

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INNATE IMMUNITY

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NUTRITION FOR MONOCYTE AND
MACHROPHAGE

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1. Omega 3 fatty acid
2. Vitamin A
3. Vitamin D
4. Vitamin E
5. Zinc
6. Selenium
7. Conjugated fatty acid

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NUTRITION FOR NATURAL KILLER
CELLS

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1. Omega 3 fatty acid
2. Vitamin A
3. Zinc
4. Conjugated fatty acid

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NUTRITION FOR DENDITRIC CELLS

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1. Vitamin A
2. Vitamin D
3. Vitamin E

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ADAPTIVE IMMUNITY

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NUTRITION FOR T AND B CELLS

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1. Omega 3 fatty acid
2. Vitamin A
3. Vitamin D
4. Vitamin E
5. Zinc
6. Selenium
7. Conjugated fatty acid

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OVERVIEW

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OVERVIEW
PEMBERIAN FISH OIL

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induces the expression of matrix metalloproteinase 12
(MMP12) 

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OVERVIEW
PEMBERIAN FISH OIL

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OVERVIEW
PEMBERIAN FISH OIL

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EPA
DHA

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EPA

United States Department of Agriculture 2016.

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VITAMIN D

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MEMBUAT MENU

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1. AKG
2. Nutrisurvey

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 DAFTAR REFERENSI

� 1. Shils ME, Shike M. Modern Nutrition in Health and

Disease. Lippincott Williams & Wilkins, 2006.
� 2. Xia S, Li X, Cheng L, et al. Fish Oil–Rich Diet Promotes
Hematopoiesis and Alters Hematopoietic Niche.
Endocrinology 2015; 156: 2821–2830.
� 3. Wilkinson AC, Yamazaki S. The hematopoietic stem cell
diet. Int J Hematol. 2018 Jun;107(6):634-641. doi:
10.1007/s12185-018-2451-1. Epub 2018 Mar 31. Review.