PHARMACEUTICAL

INDUSTRY

Yazeed Turki Hatem Alokasi

438801775
 Contents
 Introduction
 Market
 Methods to be used
 Process Description
 Process flow sheet
 Process condition
 List of equipments used
 Product specification
 Product application
 Safety information
 Troubleshooting
 KSA Plants
 Main technology
 New trend
Introduction
Pharmaceutical industry, discovery, development and
manufacture of medicines and medicines (medicines) by
.public and private institutions
The modern era of the pharmaceutical industry to isolate and
purify compounds, chemical synthesis, and computer-aided
drug design began in the nineteenth century, after thousands
of years of intuition and trial and error led humans to
believe that plants, animals, and minerals contain medicinal
properties. Setting new drug targets, obtaining regulatory
approval from government agencies, and refining
technologies in drug discovery and development are among
.the challenges facing the pharmaceutical industry today
Market
The global pharmaceutical manufacturing market size 
was valued at USD 1,325.5 billion in 2019 and is
expected to grow at a compound annual growth rate
(CAGR) of 4.6% from 2020 to 2027. Continuous
investments made by the pharmaceutical and
outsourcing firms to expand their manufacturing facilities
have positively impacted market growth. For instance, in
February 2020, AstraZeneca invested USD 133.0 million
to expand its Australian manufacturing site. Similarly, in
December 2019, a global outsourcing solution provider,
PCI Pharma Services, expanded its U.K.-based
Tredegar facility to improve its high potent drug
 .development and manufacturing capabilities
Methods to be used
Pharmaceutical Analysis: Analytical Methods

.Titrimetric techniques
.Chromatographic techniques
.Spectroscopic techniques
.Electrochemical techniques
.Kinetic method of analysis
.Electrophoretic methods
.Flow injection and sequential injection analysis
.Hyphenated techniques
Process Description
Pharmaceutical processing is the process of drug 
manufacturing and can be broken down into a range
of unit operations, such
as blending, granulation, milling, coating, tablet
pressing, filling and others. The Pharmaceutical
manufacturing process has precise requirements and
manufacturing guidelines in terms of quality. As a
result, it is crucial that pharmaceutical
manufacturing equipment complies with good
.manufacturing practices
Process flow sheet
Process conditions
In the pharmaceutical industry, fluid bed 
granulation processes require tight control to
ensure reliability. This is particularly the case
when the product characteristics add to make
the process intrinsically non-robust. Tight
process control is generally achieved by careful
and accurate control and monitoring of the
process parameters affecting the granule
wetting/drying equilibrium. However, these
parameters are prone to natural unavoidable
variation
List of equipments used
.Agitators 

.Blowers 

.Boilers 

.Capsule equipments 

.Capsule and tablet printers 

.Centrifuges 

.Chillers 

.Coaters 

.Cooling towers 

.Dryers and Granulators 

.Heat exchangers 

.High Pressure homogenizers 

.Inspection machines 
Product specification
Particle size 
Physicochemical properties such as 
refractive index, pH, melting point
Chiral identity 
Polymorphic form/amorphous content 
Water content 
Microbial content 
Inorganic impurity levels 
Products applications
Pharmaceutical applications of neural networks, a form 
of artificial intelligence, have included direct compression
of tablets and fluid bed granulation, in addition to roller
compaction. These artificial intelligence approaches
center on establishing cause and effect relationships
within data sets and then using those relationships in
“reverse” order to determine the process conditions
necessary to achieve user-specified outputs. Such
techniques are useful when gaps exist in experimental
measurements of important process parameters or when
complexities in both physical process geometry and
mechanical behavior of powders impede process
modeling efforts
Safety information
In all workplaces, employees must be mindful when it comes to health & 
safety. Workers are also legally obliged to take additional precautions
.when it comes to working in hazardous environments
all employees must comply with the 

:following basic steps 

Maintain a tidy work area 

Frequently wash hands 

Wear a laboratory coat & Wear eye protection 

Label containers correctly 

Not wear clothing that exposes the skin (eg, shorts and T-shirts) 

Regularly check that glassware is not cracked and that all equipment is 
safe to use
Keep corridors clear 

Conduct risk assessments every day 

Troubleshooting
Even well-defined pharmaceutical processes can grind to a halt when an 
unexpected HPLC peak arises during product quality control testing. We
have the capabilities (high resolution MS, GCMS, NMR) and experience to
investigate and unequivocally identify unexpected impurities with speed and
.precision

Case Study: Unknown Impurity in Drug Product 

A client was faced with production shutdown when an unexpected impurity 

arose in its QC testing of an oligopeptide product. We determined that the
impurity was in fact API-related, and arose as a consequence of reaction
with trace acetaldehyde leaching into the manufacturer’s equipment train.
Once the source was identified and remedied, production resumed without
.problem
KSA Plants
The $53 million, 75,000-square-meter (807,292- 
square-foot) Julphar Saudi Arabia plant was built by
a joint venture between the United Arab Emirates-
based Julphar Gulf Pharmaceutical Industries,
and Cigalah Group, a Saudi healthcare distributor.
Julphar claims to be the largest generic drugmaker in
.the Middle East and North Africa
Julphar will make both oral solid dose and oral liquid 
formulations. It will have the capacity to manufacture
up to 1 billion tablets, 300 million capsules and 30
.million bottles of syrups and suspensions a year
Main technology
Deep Learning in Drug R&D: Neural network models trained by large-scale chemical 
compound datasets can enhance target selection and lead compound screening (LCS)
research, reducing screening time and improving drug discovery efficiency.

Intelligent Pharmaceutical Logistics: Taking advantage of machine learning, IoT and other

advanced technologies, pharmaceutical logistics innovations include quick loading,
scheduling systems, and path optimization. Blockchain technology meanwhile can make
the entire drug circulation process traceable.

Automatic Drug Distribution: Medical robots can substitute for humans in automatic drug
delivery, sorting and dispensing tasks. By using advanced voice interaction and other
technologies, robots can also directly interact with humans and provide drugs to patients.

Medical Data Mining: With data mining, NLP and other AI technologies, researchers can
analyze large amounts of medical information such as drug data, literature data, medical
.patients and Internet data, adopting correlation analysis and generating valuable insights
New trend
Perhaps not surprisingly, we place COVID-19 first on the list. the 
implications of COVID-19 on the B2B pharmaceutical industry
and on marketing teams a few months back, so we will refrain from
going into too much detail. But COVID-19 will continue to affect
pharma in a number of ways, such as by forcing more
collaboration between organisations. Cross-industry and cross-
enterprise collaboration in areas such as research and development
is highly common, and as we all tackle a global pandemic, such
collaborative approaches within key operational departments may
become the norm and marketers will spend more time positioning
their organisations as attractive within B2B environments more
.than ever going into 2021 (we expand on this shortly)