Professional Documents
Culture Documents
PREVENTION
AND
GENETIC COUNSELLING
Guidelines
• WHO
• NCCN
• Association of Breast Surgeons (ABS)
• National Academy of Medicine
• American Cancer Society
• US Preventive Services Task Force
• American College of Radiology (ACR)
• Society of Breast Imaging (SBI)
Case Scenario
• Mrs. X is a 46-year-old woman who presents to hospital for
enquiry about breast cancer.
• She informs that her 51-year-old friend was diagnosed with
breast cancer one month ago and that she is worried about
getting breast cancer.
• On further inquiry, she gives history that she delivered her only
child when she was 32 years of age and has no family history
for breast cancer.
• She does not perform breast self-examinations and has never
had a mammogram. Mrs. X asks advice on breast cancer
screening.
INTRODUCTION
Increased risk of breast cancer with family history is known
• 20% and 25% of women diagnosed with breast cancer have a
positive family history
• But the only agent for which mature data from clinical trials are
available is tamoxifen
• The results of the NSABP P-1 trial indicated that tamoxifen
reduced the rates of invasive and noninvasive breast cancer by
49% and 50%, respectively in high risk women