Outline

• Introduction
• Acute &Chronic complication of T2DM
• Pathogenesis
• Process of T2DM
• Treatment of T2DM with Natural products
• Other Components
• Conclusion
Introduction

• Diabetes Mellitus(DM) is a complex chronic

systemic disease associated by metabolic

disorders.

• 422 million people worldwide have diabetes.

• Occur mostly in low-and middle-income countries.

Figure 1.0 indicates Diabetes Mellitus
Type 1 & Type 2 Diabetes mellitus
1. T1DM
pancreatic destruction causing a high
deficiency in insulin
2. T2DM
• insulin resistance (IR) & Insulin secretion
deficiency
• Organs destruction& complications
• High mortality due to some acute
complucations
The acute & Chronic complications of T2DM

Acute complications:
• Ketoacidosis
• The hyperglycemic hyperosmolar non
ketotic syndrome
• Hypoglycemia
Chronic complications:
• Neuropathies
• Nephropathies
• Retinopathies
• Foot ulcers
• Disorders of the microcirculation
• Macrovascular complications
Figure 1.0 shows T2DM complications
Treatement for T2DM
Anti-diabetic drugs
• Medicines to control glycemic
level
• Limit clinical application
Side effects
• Hypoglycemia, fluid retention,
osteoporosis and heart failure
Natural products(NPs)
• Herbal treatment & extracts for
treatment of disease since the
early centuries
• Plant based therapy incudes
Aloe vera, cinnamon,Ginger etc…