COVID 19

Vaccine update
 Agenda
 Tier Estimate Worksheet
 Candidate Vaccines
 Operation Warp Speed
 Vaccine Safety
 Tier Estimate Worksheet
 August 3rd deadline
 For those still needing assistance, please call me at 573-526-6643
 For Missouri National Guard or military personnel, please only count those that are
permanently stationed in your county.
 Please email the completed Tier Estimate worksheet to either
Jennifer.VanBooven@health.mo.gov or Lana.Hudanick@health.mo.gov
 Vaccine Update: Moderna
 Moderna’s COVID 19 vaccine
o Scheduled to start phase 3 trials July 27th (today)
o mRNA based (this is new technology for vaccines)
o 30,000 individuals enrolled in phase 3 trials
o Early data is showing that it produces antibodies to neutralize the virus
o Mild to moderate side effects
o 2 injections separated by 4 weeks

https://www.statnews.com/feature/coronavirus/drugs-vaccines-tracker/
 Vaccine Update: AstraZeneca & University of Oxford

 AZD1222 COVID-19 vaccine

o Presently in Phase 3 trials
o 2 dose series
o Uses a modified genetically engineered virus (new platform)
o Has been used in experimental vaccine development for a Ebola vaccine
o Side effects are mild to moderate
o Immune response is good
o Only individuals 18-55 were enrolled in the trials

https://www.statnews.com/feature/coronavirus/drugs-vaccines-tracker/
 Vaccine Update: BioNTech and Pfizer

o Phase 2b/3 late July/early August

o Depending on successful studies, may request EUA as early as October 2020 (subject to
change)
o 4 different versions are in the trial at this time 1-2 will move forward
o BNT162 Program
o BNT162b1 – most advanced, showed the ability to produce neutralizing antibodies in humans
at or above levels observed in the plasma from patients who had recovered from COVID-19
o Could be 1-3 doses in a series (still evaluating)
o mRNA vaccine platform
o https://www.businesswire.com/news/home/20200722005438/en/Pfizer-BioNTech-Announce-Agree
ment-U.S.-Government-600
 
https://www.statnews.com/feature/coronavirus/drugs-vaccines-tracker/
 Vaccine Update
o Any vaccine that is available in the Fall will be
o Limited amounts
o Targeted vaccine efforts will occur
o Still unsure on how vaccine will be initially deployed
o BI has been instructed that we will need to use the ShowMeVax Missouri’s Immunization
Information System (IIS) to track doses once general population vaccination begins
o Still waiting to see who will be prioritized
o Advisory Committee on Immunization Practices (ACIP) meets mid August and September
before regularly scheduled meeting in October
 Operation Warp Speed
 Key players: CDC, HHS, FDA, NIH, DoD
 Aimed at accelerating the production of COVID-19 vaccine(s) while maintaining proper safety
and efficacy measures
 Developing details around vaccine distribution and priority groups
 Closed Door meeting on Wednesday, July 22nd
 Hopeful some decisions were made regarding priority groups and vaccine distribution.
 Vaccine Safety

o All adverse events that occur will need to be reported online at VAERS
o CDC and HHS are in the process of improving the system to handle the vaccine
o Once vaccine is deployed:
o VAERS will start collecting reports of adverse events for COVID-19 vaccine
o All health care providers will need to report online at https://vaers.hhs.gov/
o Each Monday Missouri’s Vaccine Safety Coordinator will be given an updated
spreadsheet of reported events for Missouri
o Redacted data will be made available on CDC WONDER
 Vaccine Safety
o How will the state be determined for each COVID-19 VAERS report?
o Patient state of resident – is always first
o Where the individual was vaccinated
o Where the VAERS report was made
o How will deaths following vaccination be reported?
o Should a death occur then the Vaccine Safety Coordinator will receive an
email
 What steps should be take now
o Ensure all staff who administer immunizations know how to report to VAERS
o Any communication with immunization providers in the county should include
reporting vaccine adverse events in VAERS
o If providing any education to an immunizer, make sure they know how to report
to VAERS
o If you need help or education on VAERS please contact the Bureau of
Immunizations
 Other information
o Guidance will be sent out to all of your VFC coordinators on Planning Vaccination Clinics
Held at Satellite, Temporary or Off-Site Locations
o The guidance is broken down into four categories:
o Planning activities (
https://www.cdc.gov/vaccines/hcp/admin/mass-clinic-activities/planning-activities.html)
o Pre-clinic activities (
https://www.cdc.gov/vaccines/hcp/admin/mass-clinic-activities/pre-clinic-activities.html)
o During the clinic activities (
https://www.cdc.gov/vaccines/hcp/admin/mass-clinic-activities/during-clinic-activities.html
)
o Post-clinic activities (
https://www.cdc.gov/vaccines/hcp/admin/mass-clinic-activities/post-clinic-activities.html)
 Next Steps
 Next Call August 31st 3:30-4:30
 Any updates between now and then I will try to provide in an email but may need to schedule
an earlier call.
 Still working to secure PPE and vaccine administration supplies for distribution to LPHAs and
other community partners engaged in vaccination efforts.
 Any questions?