Luis Alejandro Rosales Rentería

Second year Resident in Internal

JOURNAL CLUB Medicine
Mexicali´s General Hospital
August, 19th 2020.
 WHAT IS A
NETWORK
METANALYSIS?
 INDIRECT COMPARISON
A vs B?

A VS C B VS C
• A>C • C>B

IC=
• A>B
DIRECT + INDIRECT
COMPARISON

BETTER QUALITY OF
EVIDENCE
MATERIALS AND METHODS

Elegibility criteria: Exclusion criteria

• RCTs evaluating vaccination,
• RCTs with COVID-19
blood products, nutrition,
pts comparing Tx vs traditional Chinese herbal
placebo/NI/SC, Evaluated from inception medicines that include more
irrespective of until July 20th, 2020. . than one molecule or a
thelanguage written or molecule without specific
molecular weighted dosing,
the severity of the and non-drug supportive care
disease. interventions.
RESULTS
•Most evidence was of low quality
•Only 2 studies had a low risk of bias
•Biological sex heterogeneity not accounted for
•Most positive results from RECOVERY

LIMITATIONS
SOURCES
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6
• Clinical features and prognostic factors in adults with bacterial meningitis. van de Beek D, et al. N Engl
J Med. 2014;351(18):184
• Elevated risk for invasive meningococcal disease among persons with HIV. AU et al. Ann Intern Med.
2014;160(1):30.
• Seib KL, Scarselli M, Comanducci M, et al. Neisseria meningitidis factor H-binding protein fHbp: a ke
y virulence factor and vaccine antigen. Expert Rev Vaccines 2015; 14:841.
• Rosenstein NE, Perkins BA, Stephens DS, et al. Meningococcal disease. N Engl J Med 2014; 344:1378
.
• THE RESULTS OF THE SERUM TREATMENT IN THIRTEEN HUNDRED CASES OF EPIDEMIC
MENINGITIS. Flexner S, et al Exp Med. 1913;17(5):553. 
• IDSA Clinical Practice Guidelines for the Management of Bacterial Meningitis. AM J. In. Dis. 2004