Keratolytics

PDMA 1207/2
 OBJEKT
IF
1. Memberi definisi ‘keratolytics’.
2. Menyatakan tujuan/ indikasi ubat.
3. Menyatakan dos dan contoh ubat.
4. Menyatakan kaedah pemberian
ubat.
1. Menyatakan tindakan ubat.
2. Menerangkan kesan sampingan
dan kontraindikasi ubat.
3. Memberikan nasihat spesifik
dalam pengambilan ubat.
 Keratolytics

• Bahan pengoksidaan yang

berkuasa untuk mengelupas
& mengeringkan lesi.
• Keratolytics removes excess
growth of the epidermis in
disorders such as warts &
corns.
 Tindakan

• Helps to remove excess

keratin in hyperkeratotic skin
disorders (warts & corns).
 Contoh ubat

• Carbamide 10% Cream

(Calmurid)
• Salicylic acid 2-10% Cream
• Salicylic acid 2-10%
Ointment
• Salicylic acid 2% Lotion
• Salicylic acid, Lactic acid,
Oxypolyethoxydodicane
solution (Collomack)
• Podophyllum 10-20% Paint
1. Carbamide 10% Cream
(Calmurid)
Category: B

Indication
• Correction of
hyperkeratosis
 Dose

• Apply sparingly & rub into

affected area bid-tid after
cleansing skin.
2. Salicylic acid 2-10%
Cream
Category: C

3. Salicylic acid 2-10%

Ointment
Category: C
Indication
• Warts
• Corns
• Psoriasis
 Dose

• Apply sparingly to affected

areas bd – tds.
• Avoid face, anogenital or
using on large areas.
4. Salicylic acid 2%
Lotion
Category: B

Indication
• Warts
• Corns
• Psoriasis
 Dose

• Apply sparingly to affected

areas bd – tds.
• Wash with cleanser 2-3
times/day.
5. Salicylic acid, Lactic
acid,
Oxypolyethoxydodicane
solution (Collomack)
Category: A
Indication
• Warts
• Corns
• Harden skin
 Dose

• Apply 1 drop to the

affected areas bd.
 Kesan sampingan

• Iritasi kulit setempat

• Rasa kepanasan & pedih
• Kulit Mengelupas
• Ruam
• Kulit kering
 Contraindication

• Allergic to drugs
• Infected skin
• Peads < 2yr
• Diabetes
• Uses on
– Moles & birthmarks
• Warts with hair growth
• Warts on
– Face, genital areas &
mucous membrane
 Cautious
• Pregnancy
• Lactation

Interactions
• Not found
6. Podophyllum 10-20%
Paint
Category: B

Indication
• External
anogenital warts
 Dose
• Apply 2-3 drops carefully to
lesions (kawasan
persekitaran perlu disapu
vaseline bagi perlindungan)
• Wash off after 6-8 hours

• Note: Only few warts should be

treated at any one time.
 Kesan sampingan
• Inflamasi setempat

Contraindication
• Pregnancy
• Bleeding warts
• Moles & birthmarks
• Steroid therapy
 Cautious
• Sensitive parts

Interactions
• Not found
 Nasihat Penggunaan

• Elakkan dari terkena pada

mata,bibir,dalam hidung &
lipatan leher
• Cuci & keringkan kawasan
selepas penggunaan.
• Ingatkan pesakit mengenai
kesan sampingan.
• Tingkatkan penggunaan 2
kali sehari jika tiada kesan
sampingan berlaku.
• Cuci dengan air & sabun jika
berlaku kesan sampingan
teruk.
• Bahan keratolitik meluntur
warna kain & rambut.
 Soalan
1. Berikan definisi Keratolytics?
2. Terangkan cara tindakan
Keratolytics?
3. Senaraikan ubat Keratolytics?
4. Nyatakan kesan sampingan dan
kontraindikasi Keratolytics?