Glycoprotein

By Group (II)
•Mehwish Rahman(bi2bu19
•Shumaila Gull(bi15bu19)
•Abida Khan(bi09bu19)
 What are Glycoprotein?
•Glycoprotein are proteins that contains
oligosacrride chain (glycan) to polypeptide
side chain.
•Most surface proteins are glycoprotein.
•Eukaryotic glycoprotein are usually N-linked
to Asparagines or O-linked to Serine or
thorinin.
 How the protein links to glycan?
• The process by which protein get linked to
glycan is called glycosylation.
• There are two types of glycosylation .
1. N-Glycosylation
2. O-Glycosylation
 N-Glycosylation
• Chain of 14 residues added as polypeptide
comes off ribosome in RER.
• At Golgi apparatus , glycosidase remove some
residue and glycotransferase add new
monosacride.
Simply the amide group of asparagines which is
nucelophile react with sugar. So because of
amide group, N it is known as N-Glycoslation.
N- Glycosidic linkage
 O-Glycosylation
• When the nucelophile oxygen of sugar make
Glycosidic linkage with Serine or Thorinin the
process is known as O-glycosylation.
• This process is happening in Golgi body.
O-Glycosidic linkage
 Types of glycoprotein
There are three types of glycoprotein:
Glycoprotein:
1. which have a major part of proteins and minor part of
glucose.
2. Most oh hormones are glycoprotein
Proteoglycan:
3. They have a major part of suger and a minor portion of
protein.
4. Exmple is glycosamine
5. Mostly present in joints.
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Mucin:
1. Major part of these glycoprotein is sugar and
minor part is protein.
2. Example: N-acetylglycosamine
3. muscus
Principle sugar and their glycoprotein in
human body:
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Functions served by glycoprotein:
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