Virology

Relication of
T-Phages
T-phages
Replication

• Attachment

• Penetration

• Uncoating

• Biosynthesis

• Release
T-phages
Attachment
Specific receptors

Techoic acid

Lipids

Proteins

flagella

On specific bacterial
hosts
 T-phages
Penetration • Leave capsid
outside
T-phages
 T-phages

Biosynthesis • Bacterial ribosomes translate

viral proteins

• Proteins modify bacterial RNA

polymerase

• Proteins for new virions

 T-phages
Assembly

• T4: helper proteins required

• Base plates assembled first

• Tails built afterwards

• Heads constructed separately

• Whole process takes 15 minutes

 T-phages
Release

• Lysis

Tailed phages

endolysin

• Extrusion

enveloped

END • Budding

• Secretion