Fluorescence Based Sensor

Array
Background: articles that describes the
origin/history of the analytical method/application

Ionic liquids (IL) received great interest in the past decade both in
chemical and industrial applications. Its origin, however, is traced back
to mid-19th century via the formation of ‘red oil’ during a Friedel-Crafts
reaction (Azevedo et.al., 2020). Ionic liquids have lower melting points
as compared to inorganic salts due to the poor packing of ions. One of
its applications is modifying traditional dyes. IL-modified methyl-red
and methyl orange based dyes showed enhanced solubility and can be
used a sensitive indicator in both aqueous and non-aqueous solutions
which is better than its traditional counterpart (Zhang et.al., 2011)
Current applications: articles that describe how a group
of researchers (e.g. mentioned in the review article)
collected data and analyzed them in the last 5 years,
using your chosen method/application
The original article from the review journal is taken from Das et. al.
(2013) entitled “Ionic Liquid-based fluorescein colorimetric pH
nanosensors”. Their group successfully synthesized two fluorescent pH-
dependent ionic liquid-based nanomaterials using ion metathesis
reaction.
In the following year, this same team
focused on Ionic liquid in creating an
optoelectronic sensor which can
discriminate cigarette brands. The digital
data generated from the IL-based sensor
arrays were used to develop a predictive
model in identifying various analytes.
They also have developed this sensor
array on different matrices such as glass
microfiber filter papers, cotton threads,
silica and alumina TLC plates.
They also continued the project on ionic liquid-based colorimetric sensor for
solvent discrimination. Their team have successfully discriminated closely
related organic solvents. The result of their study shows 96.4 % identification
accuracy for eight different pure alcohols and 100% accuracy for ethanol-
methanol mixtures.
In 2016, their studies shifted from
ionic liquids to GUMBOS (group of
uniform materials based on organic
salts) as a new florescence-based
sensor. Their study demonstrated the
use of selective fluorescent probe to
discriminate protein and protein
mixtures. They have done this by ionic
modification of TNS (6-(p-toluidino)-2-
naphthalenesulfonate) to produce
GUMBOS
Figures of merit: one of the research article in (b) that describes
the sensitivity and selectivity of the method compared to
previous or alternative methods; or an article comparing results
between research groups
Currently, the trend now is in the use of
GUMBOS as a fluorescence-based sensor
though there still papers focusing more on
the modification of ionic liquids.
Fluorescence-based nanosensors are used
for selective imaging of cancer cells. A study
of McNeel et. al. (2019) synthesizes a sensor
composed of three ionic species
(fluorescein, rhodamine B, and
tetradecyltrihexyl phosphonium) ions. In
vitro fluorescence micrsocopy of the
synthesized nanoGUMBOS showed higher
uptake and high fluorescence intensity ad
compared with normal cells.
2019 cancel cells determination using
GUMBOS
2020 Protein determination GUMBOS