OBSTRUCTIVE AIRWAYS

DISEASE

Wisconsin University Hospital.

Department of Medicine
Emphysema. PA Chest radiography in a patient with severe
emphysema secondary to alpha-1 antitrypsin deficiency
Emphysema. Lateral chest radiograph of the same patient
Emphysema. “Billowy”, over-expanded lungs in a post mortem
specimen from a patient with emphysema
Emphysema. Graphic depiction of centrilobular versus panlobular
emphysema
Emphysema. Cross section of a whole lung showing areas of
emphysema
Emphysema. Cross section of a whole lung showing changes of
bullous emphysema
 Emphysema. High resolution CT scan of lung showing
emphysematous changes. (The infiltrates are unrelated to the patient’s
emphysema)
Emphysema. PA chest radiograph of a patient with bullous
emphysema, most notable at the left base
Emphysema. Photomicrograph of alveolar destruction in emphysema
Asthma. PA chest radiograph in a patient with severe asthma
Asthma. Lateral chest radiograph in the same patient
Asthma. Hyper-inflated lungs in a patient dying in status asthmaticus
 Asthma. Bronchial epithelium in a patient with asthma. Note
denudation of bronchial mucosa, infiltration of mucosa and sub-
mucosa with mast cells and eosinophils, and edema of submucosa
Asthma. Nasal polyp removed from a patient with asthma
Asthma. Thin section from a patient dying of status asthmaticus. The
bronchi are filled with mucus
Asthma. Large airway cast of inspissated mucus in a patient dying of
status asthmaticus
Asthma. Cross section of a lung of a patient dying in status
asthmaticus showing mucus plug in the bronchi
Chronic bronchitis. PA chest radiograph of a patient with chronic
bronchitis. There is borderline cardiomegaly, depressed
hemidiaphragms, and increased interstitial markings
 Chronic bronchitis. Histologic section of bronchial mucosa in a
patient with chronic bronchitis. There are increased numbers of
goblet cells in the bronchial epithelium, and the basement membrane
is markedly thickened
Chronic bronchitis. Histologic section of lung from a patient with
chronic bronchitis. There is evidence of mucous gland hyperplasia
and chronic inflammation
 Chronic bronchitis. Scanning electron micrograph of bronchial
epithelium in a patient with chronic bronchitis showing loss of cilia.
Only a few clusters of cilia remain on the cell surface
Chronic bronchitis. Histologic section of bronchial epithelium in a
patient with chronic bronchitis showing squamous metaplasia
Cystic fibrosis. PA chest radiograph of a patient with cystic fibrosis.
There is scarring, bronchial cuffing and bronchiectasis
Cystic fibrosis. Longitudinal bronchial sections showing cylindrical
bronchiectasis
Cystic fibrosis. Bronchiectasis seen in cross section
THANKS