Pharmacological Properties

of Corticosteroid

Trully deti Rose Sitorus, dr.,Msi.,SpFK

Depatement of Pharmacology & Therapy
Faculty of Medicine Universitas Padjadjaran
 Curriculum Vitae

Truly Sitorus., dr.,Msi.,SpFK

dr : Fak Kedokteran UNPAD

Magister : Farmasi Institut -Teknologi Bandung
Sp : Farmakologi Klinik Universitas Indonesia

Departemen Farmakologi & Terapi FK UNPAD

SMF Farmakologi Klinik -RS Hasan Sadikin
• Trimakasih Angkatan 2017
Membuat tugas dengan baik..
 How to learn Pharmacology ?

Mrs. X , 54 year old, came to Puskesmas

due to swelling and pain on her unkle,
since 2 days, she can not walk

Diagnose : Arthritis .
Treatment :
Prednisone , tablet, 5 mg, twice a day for 5 days
 Inflammation
Stimulus

Disturbance of cell membrane ( phospholipids )

Release phospholipase enzyme

Release arachidonic acid

Stimulate lipooxygenese cyclo oxygenese ( cox) enzyme

leucotrientenes Synthesis of PG tromboxane

Bronchial contrition Bronchial Fever, Pain, Edema,

asthma Erythema

07/16/2021 Truly –PP of a drugs 5

 How to learn Pharmacology ?

 What is prednisone ?
Prednisone  What group ?
 How can it treat or reduce the
disease / symptom ?,
 What are the pharmacology
effects ?
 Is there any Side effects ?
 What are the indication ?
 What are the contraindication ?
 How are the Pharmacokinetics ?
 How to learn Pharmacology ?

1. Name of the drugs

2. Mechanism of Action
3. Pharmacological
Effects
4. Drug Indication Pharmacological
5. Drugs Contra Properties of Drugs
Indication
6. Pharmacokinetics
7. Dosage Regimen
8. Drug Interaction
 How to learn Pharmacology ?

Pharmacological Properties of a drug

TrulyS Pharmacology Concept Mapping

TrulyS Concept Mapping Pharmacology
Class

Mechanism of Action

Main Receptor Others Receptor

Main Effect Side Effects

Predictable Un predictable

Indication Contraindication
A :
Dosage
D :
Regimen
M: Drug Interaction

E :

Advantages Disadvantages
 What is prednisone
Prednisone is a synthetic of corticosteroid hormone

Cortisol
Hormone

GR : immune system & metabolism

 MR : salt –retaining activity
 AR : Androgenic or estrogenic receptor
1.CLASS OF THERAPY
Corticosteroid
 Class of therapy
Member of Corticosteroid class :
Cortisone
Prednisone
Methylprednisolone
Dexamethasone

Beclomethasone
 Hydrocortisone
 Mometasone
Triamcinolone

 Beclomethasone
 Budesonide
 Fluticasone

 Methylprednisolone
 Triamcinolone
 2.MECHANISM OF ACTION

Mechanism of Action
Mechanism of action of CS Pro-opiomelanocortin,
osteocalcin,proliferin
Ik B keratins, interleukin 1B

NF-kβ
Others

Cytokine
Annexin
Pro inflammatory
cPLA2α

IL1 -IL6 -TNFα

Phospholiphase A2

Prostaglandin Leucotrient

PAF
07/16/2021 14
 3. RECEPTOR

Prednisone

Glucocortikoid Mineralocorticoid Androgenic

Receptor Receptor Receptor

All tissues/ cells

 4.PHARMACOLOGY EFFECTS
Glucocorticoid
Antiinflmmatin
Receptor
Antiproliferatif
Immunosupresive
Vasoconst5rictor

Prednisone

↑↑Glucose
07/16/2021 TS corticosteroid peralumuni 2017 16
 4. PHARMACOLOGY EFFECTS
• mMineralocorticoid Receptor

Sodium – water
retention
4. PHARMACOLOGY EFFECTS

EFFECTS

MAIN EFFECTS
SIDE EFFETS/ ADR

CONTRAINDICATION
INDICATION
 INDICATION
1. Replacement therapy for primary
adrenocortical insufficiency (Addison disease):
2. Relief of inflammatory symptoms
3. . Treatment of allergies
 OTHERS SIDE EFFECTS

• Growth retardation
• Peptic ulcer
• Moon face- buffalo hump
• High level of glucose – Cholesterol
• Electrolyte disturbance
• Ocular : glaucoma, vision loss
• Hirsutism, amenorrhea

07/16/2021 TS corticosteroid 2017 20

CONTRAINDICATION
TrulyS Concept Mapping Pharmacology
Class

Mechanism of Action

Main Receptor Others Receptor

Main Effect Side Effects

Predictable Un predictable

Indication Contraindication
A :
Dosage
D :
Regimen
M: Drug Interaction

E :

Advantages Disadvantages
 TrulyS Concept Mapping Pharmacology
Class

MOA : modifying protein synthesis, inhibit Phospholiphase enzyme

Glucocorticoid, all cells Mineralocorticoid

Side Effects

EFFECTS: Predictable
Un predictable
↑↑glucose. Osteoporosis
Inflammation – ↓↓immun. Atrophy ,
Allergy
Immuno suppressive Idiocyncartion
others

INDICATION
CONTRAINDICATION
 TrulyS Concept Mapping Pharmacology
Dosage Regimen PHARMACOKINETICS
Strong : 5 mg A : Rapid absorbed
Preparation : tablet
Freq/ interval : 12 h D : >90 %- prot bound Drug Interaction
Time : post coenam/
after meal M: Liver
E
: Kidney

Advantages : Disadvantages
TrulyS Concept Mapping Pharmacology
Class

Mechanism of Action

Main Receptor Others Receptor

Main Effect Side Effects

Predictable Un predictable

Indication Contraindication
A :
Dosage
D :
Regimen
M: Drug Interaction

E :

Advantages Disadvantages
 Receptor
Dexametasone Prednisone Methylprednisolon

Glucocortikoid Mineralocorticoid Androgenic

Receptor Receptor Receptor

All tissues/ cells Kidney - others