‫بسم هللا الرحمن الرحيم‬

‫‪Cell injury‬‬
Cloudy swelling: reversible cell injury, enlarged cells
.with faint pale cytoplasm
Cloudy swelling: reversible cell injury, enlarged cells
Cloudy
.with swelling
faint pale cytoplasm
Fatty changes: reversible cell injury, liver cells with large
(Hepatocytes):
Nuclear changes, (Pyknosis – dark skrink nuclei), (Karyorrhexis –Fragmented
Kidney : coagulative necrosis due to renal ischemia
Gross : Wedge shape pale area sharply demarcated.
Coagulative necrosis :
Microscopical : Wedge shape , pale, sharply demarcated.
Kidney:
Coagulative necrosis:
Cause :Ischemia
Preserved cell out lines ,
Glomeruli & renal tubules
:Coagulative necrosis
Increase cytoplasmic eosinophilia (cytoplasm of effected cardiac muscle with dark pink
. color)
Bowel : ischemic necrosis:
Gross : Dark brown in color
Liquifactive Necrosis: (brain).
Cause : (ischemia) . Gross complete lose of architecture and brain
tissue changed into structure less fluid like material.
Liver abscess : liquifactive necrosis complete lose of
architecture and hepatic tissue changed into structure less
T.B. Lung.(gross)
Caseous necrosis
(apical lesion with
friable yellowish –
whitish cheese
martial)
Caseous necrosis “granuloma” : (lung T.B.)
1- caseous granuloma.
2- langhan’s giant cell
langhan’s giant cell “horse shoe appearance of nuclei”
T.B Bacilli (A.F.B. Stain). Sputum cytology
Fatty necrosis: (mesentery)
Cause :Pancreatitis : (activation of lipase enzyme).
Arterial wall: Fibrinoid necrosis:
Cause :Hypertension:
Intense eosinophilic material deposit within the arterial wall onion skin appearance
Thank you