PREPARATION OF IV ADMIXTURE

ACTIVITY V
 What is IV admixture?

 It is combination of one or more sterile products added to an

IV fluid for administration or Pharmaceutical mixture of two
or more drugs into a Large bag or bottle of I.V fluid. It must
be sterile and pyrogen free Aseptic techniques are used to
mix the products.

 requires the measured addition of a medication to a 50 mL or

greater bag or bottle of IV fluid
 Where are IV medications/admixtures
prepared in the hospital?
 Many IV therapies ordered for acute care hospital patients
must be prepared in a compliant IV compounding room
located within the hospital pharmacy. All sterile
compounding in a community pharmacy should be
performed in a laminar air flow hood. These compounds
require pharmacy staff to obtain materials, prepare the
medication and be reviewed by a pharmacist prior to
delivery to the patient care area for use.
What is laminar flow hood (LFH)? Why is it necessary
to use LFH in preparing sterile products?

 A Laminar flow hood/cabinet is an enclosed workstation that is

used to create a contamination-free work environment through
filters to capture all the particles entering the cabinet.

 It is necessary to use LFH in preparing sterile products because

sterile products must be free from any contamination or viable
microorganisms. Using a laminar flow hood helps to keep the
sterility and integrity of the product.
 What is the most common cause of contamination in an IV
admixture? What is the most important aspect of preparing
IV admixtures that can decrease the risk of contamination?

 Poor manipulation of the syringe is the most frequent cause of

contamination.

 Always minimize clutter. Waste and other items should never

enter the hood. All calculations should be done before entering
the hood. Wash hands and arms before compounding or re-
entering the hood. Also, remove any jewelry from the hands and
wrists. It is important that you keep your hands within the cleaned
area of the hood as much as possible.  Do not touch your hair, face
or clothing. Excess dust should be removed from items before
introducing them into the hood
Why reducing particulate is counts in
an IV room important?
 The reducing of particulate is a count in an IV room important in
order to remove contaminants

 Particulate matter refers to unwanted particles present in

parenteral products. Particulate matter that is injected into the
bloodstream can cause adverse effects to the patient. Some
examples of particulate matter are glass fragments, hair, lint or
cotton fibers, cardboard fragments, undissolved drug particles,
and fragments of rubber stoppers, known as cores. Improvements
in manufacturing processes have greatly reduced the presence of
particulates in commercially available products. Similar care must
be taken in the pharmacy so that particulate matter is not
introduced into products.
 What are the different types of incompatibilities
encountered in preparing IV admixtures? Describe
each incompatibilities
 Physical Incompatibilities- the incompatibility that is more on
solubility changes and container interactions

 Chemical Incompatibilities- the results from the molecular changes or

the rearrangement and leads to chemical decomposition.
 
 Therapeutic Incompatibilities- result of antagonistic pharmacological
effects of several drugs in one patient. Example Intervention Heparin
and antibiotics It is best to avoid mixing heparin with antibacterial
preparations because Heparin can affect the stability of certain
antibiotics.
 
 Drug IV Container Incompatibilities- incompatibility that arises from
the chemical reaction of the drug and the Intravenous container.
 Define IV push.

 Method of giving concentrated doses of medication directly into

the vein (is administered over 1 to 5 minutes)

 Intravenous or IV push is the rapid administration of a small

volume of medication into the patient's vein via a previously
inserted intravenous catheter. This method is used when a rapid
response to a medication is required, or when the medication
cannot be administered via the oral route.
 Name three medications that can be
administered by IV push.
 Chloramphenicol - IV push, Inject over at least 1 min

 Ampicillin - IV push, Slow IV injection IM, Inject over 3 to 5 min for

125-, 250-, and 500-mg doses Inject over 10 to 15 min for 1- and 2-g
doses

 Aztreonam - IV push Intermittent IV infusion IM, Inject over 3 to 5

min, directly into vein or through the tubing of a running
compatible IV infusion
Draw a syringe and label each part
Draw a needle and label each part
 CONCLUSION:

The preparation of IV admixture is not that easy. We must be extra careful in

preparing it that is why we use a laminar flow hood or cabinet. This is necessary
because in preparing sterile products it must be free from any contamination or
viable microorganisms. Using a laminar flow hood helps to keep the sterility and
integrity of the product. The most common cause of contamination in an IV
admixture is the poor manipulation of the syringe. And we can decrease the risk of
contamination by always minimize clutter, wash hands and arms before
compounding or re-entering the hood and many others.

There are different types of incompatibilities also that we can encounter in

preparing IV admixtures such as physical incompatibilities, chemical
incompatibilities, therapeutic incompatibilities and drug IV container
incompatibilities. I also identify the different parts of the syringe: plunger top,
bassel, plunger seal, scale, and adaptor. I also have identified the different parts of
the needle: bevel, shaft, hub, adaptor and gauge number.
 REFERENCES

 https://
www.slideshare.net/RizwanAli118/iv-admixture-and-types-of-iv-admixtu
re

 https://
www.slideshare.net/jeff_bd/hospital-pharmacy-report-intravenous-admi
xtures-11985459

 https://globalrph.com/aseptictechnique/#:~:text=Poor%20manipulation
%20of%20the%20syringe,should%20never%20enter%20the%20hood
.

 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6102793/

 https://eggsinoregon.wordpress.com/2013/01/02/shots-shots-shots-shot
s-shots/syringe-parts/#
main