PHOSPHOLIPID

SYNTHESIS
SYNTHESIS OF PHOSPHOLIPIDS
Occurs in smooth endoplasmic reticulum
SYNTHESIS OF PHOSPHOLIPIDS (SER)

1. formation of lecithin and cephalin

2. synthesis of phosphatidylserine
3. formation of phosphatidylinositol
4. synthesis of phosphatidyl glycerol and
cardiolipin.
5. formation of plasmalogens and PAF.
Formation of lecithin

 1. Choline phosphocholine
ATP ADP
 2. phosphocholine CDP-choline
CTP PPi
 3. CDP-choline + 1,2 diacylglycerol
Lecithin (phosphatidylcholine)
 Formation of cephalin

 1. Ethanolamine phosphoethalonomine
ATP ADP
 2. phosphoethalonamine CDP-ethalonomine
CTP PPi
 CDP-ethalonomine + 1,2 diacylglycerol cephalin
(phosphatidyl ethanolamine)
Formation of lecithin and cephalin
 Synthesis of phosphatidylserine

1. phosphatidyl ethanolamine + serine

phosphatidylserine + ethanolamine
2. Phosphatidylserine phosphatidyl ethanolamine
CO2
Synthesis of phosphatidylserine
 Formation of phosphatidylinositol

1. Phosphatidic acid + CTP CDP- diacylglycerol

2. CDP-diacylglycerol + inositol phosphatidylinositol
CMP
Synthesis of phosphatidylinositol
Synthesis of phosphatidyl glycerol and cardiolipin

1. CDP-diacylglycerol + glycerol-3-phosphate

phosphatidyl glycerol 3 phosphate. CMP

2. phosphatidyl glycerol-3-phosphate
phosphatidyl glycerol H2O Pi
2. phosphatidyl glycerol cardiolipin
phosphatidyl glycerol glycerol
Synthesis of Cardiolipin and Glycerol
Synthesis of plasmalogens and PAF
 Dihydroxiacetone phosphate + acyl CoA → 1-
acyldihydroxiacetone phosphate.
 1-acyldihydroxiacetone phosphate + Ether → 1-
Alkyldihydroxiacetone phosphate
 1-Alkyldihydroxiacetone phosphate → 1-
Alkyglycerol 3-phosphate.
 1-Alkylglycerol 3-phosphate + acyl CoA. → 1-
Alkyl 2 acylglycerol 3-phosphate
 1-Alkyl 2 acylglycerol+ CDP-ethanolamine → 1-
Alkyl 2 acylglycerol 3 phosphoethanolamine →
plasmalogen