Acid–base measurements are made in the blood, but they

are the same in the ISF space. Because [HCO3−] is calculated

from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.
 Acid–base measurements are made in the blood, but they
are the same in the ISF space. Because [HCO3−] is calculated
from pH and pCO2, it represents the plasma concentration of
[HCO3−]. As calculated by blood gas autoanalyzers, the
reported BE reflects the difference between the normal and
actual buffer base concentrations. However, intracellular
acid–base status cannot be measured in clinical practice.
Because CO2 diffuses across cell membranes much more
rapidly than HCO3−, it is possible for rapid changes in pCO2
to change the acid–base profile of the two compartments in
different directions and at different rates. When attempting
to treat acid-base disorders, the clinician must consider the
possible consequences, such as worsening intracellular
acidosis in the face of alkalinization of the ECF with infusions
of bicarbonate.