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Antiasthmatics
Antiasthmatics
1. Salt complex :
increased water solubility without
augmentation of pharmacological
action , such as :
aminophylline (氨茶碱)
choline theophylline (胆茶碱)
2. Agent of delayed release :
//Indications :
• Bronchial asthma (+βreceptor agonist)
•Chronic obstructive lung diseases
•Cardiogenic asthma
•Sleep apenea syndrom
//Adverse effect :
it has a narrow therapeutic window and its
therapeutic and toxic effects are related to its
plasma concentration.
<20mg/L : nausea, vomiting, headache,
anxiety, abdominal discomfort
20-40mg/L: arrhythmia
Ⅲ. Muscarinic antagonist :
Ipratropium bromide ( 异丙托溴铵 )
Ipratropine( 异丙托品 )
//Mehanism :
act by blocking muscarinic receptors
esp. the M3 subtype , which responds
to this parasympathetic bronchial
constrictor tone .
//Route of administration :
metered dose inhaler
//Indication :
used as adjuncts to ß2-adrenoceptor
agonist in treatment of asthma and more
effective in vagus-induced asthma .
//Therapeutic note :
synergism when administered with
ß2-adrenoceptor agonist.
Ⅳ. Anti-inflammatory drug
Glucocorticoids include :
beclomethasone ( 倍氯米松 )
budesonide (布地奈德)
//Mechanism :
depress the inflammatory response in
bronchial mucosa thus diminish bronchial
hyperresponsiveness.
Anti-inflammatory effect
Immunosuppressive effect
Increase the response to catecholamines
Inhibit the activity of PDE
Adenoceptor-upregulation
//Route of administration :
• orally i.v
used for : severe asthma
status asthmaticus
• metered dose inhaler
//Indications :
Because of the efficacy and safety of inhaled
corticosteroids, they are now routinely prescribed
for patients who require more than occasional
inhalations of β agonist for relief of symptom.
// Adverse effect:
Oropharyngeal candidiasis