The digestive system consisting of the digestive tract and accessory organs, functions primarily to break down and absorb nutrients from food and to eliminate wastes The digestive system (alimentary system) consists of a muscular tube, the digestive tract, also called the gastrointestinal (GI) tract, Or alimentary canal, and various accessory organs. The digestive tract begins at the oral cavity (mouth). It continues through the opharynx (throat), oesophagus, ostomach, osmall intestine, and olarge intestine, which opens to the exterior at the anus. Accessory digestive organs include the teeth, tongue, and various glandular organs, such as the salivary glands, liver, and pancreas, as well as the gallbladder, which only has a secretory function. LAYERS OF THE GI TRACT The wall of the GI tract from the lower esophagus to the anal ca- nal has the same basic, four-layered arrangement of tissues. The four layers of the tract, from deep to superficial, are the mucosa, submucosa, muscularis, and serosa/adventitia THE PERITONEUM The peritoneum is a continuous, glistening, and slippery transparent serous membrane. It lines the abdominopelvic cavity and invests the viscera. The peritoneum consists of two continuous layers: the parietal peritoneum, which lines the internal surface of the abdominopelvic wall, and the visceral peritoneum, which invests viscera such as the stomach and intestines. Like the overlying skin, the peritoneum lining the interior of the body wall is sensitive to pressure, pain, heat and cold, and laceration. Pain from the parietal peritoneum is generally well localized. The visceral peritoneum is insensitive to touch, heat and cold, and laceration; it is stimulated primarily by stretching and chemical irritation. The peritoneal cavityis within the abdominal cavity and continues inferiorly into the pelvic cavity. It contains no organs but contains a thin film of peritoneal fluid, which is composed of water, electrolytes, and other substances derived from interstitial fluid in adjacent tissues. Peritoneal fluid lubricates the peritoneal surfaces, enabling the viscera to move over each other without friction, and allowing the movements of digestion. NEURAL INNERVATION OF THE GI TRACT The gastrointestinal tract is regulated by an intrinsic set of nerves known as the enteric nervous system and by an extrinsic set of nerves that are part of the autonomic nervous system. Enteric Nervous System The neurons of the ENS are arranged into two plexuses: The myenteric plexus and The submucosal plexus The myenteric plexus, or plexus of Auerbach, is located between the longitudinal and circular smooth muscle layers of the muscularis. The submucosal plexus, or plexus of Meissner is found within the submucosa. The plexuses of the ENS consist of motor neurons: controls GI tract motility (movement) interneurons, and: interconnect the neurons of the myenteric and submucosal plexuses. sensory neurons: detect stimuli in the lumen of the GI tract. chemoreceptors mechanoreceptors AUTONOMIC NERVOUS SYSTEM The vagus (X) nerves supply parasympathetic fibers to most parts of the GI tract, with the exception of the last half of the large intestine, which is supplied with parasympathetic fibers from the sacral spinal cord. THE ORAL CAVITY The oral cavity, which contains the tongue, teeth, and Salivary glands, functions in the ingestion an mechanical digestion of food. is formed by the cheeks, hard and soft pal-ates, and tongue Buccinator muscles and connective tissue lie between the skin and mucous membranes of the cheeks. The lips or labia are fleshy folds surrounding the opening of the mouth. They contain the orbicularis oris muscle and are covered externally by skin and internally by a mucous membrane. The inner surface of each lip is attached to its corresponding gum by a midline fold of mucous membrane called the labial frenulum. Hanging from the free border of the soft palate is a fingerlike muscular structure called the uvula. During swallowing, the soft palate and uvula are drawn superiorly, closing off the nasopharynx and preventing swallowed foods and liquids from entering the nasal cavity. The functions of the oral cavity include (1) sensory analysis of food before swallowing; (2) mechanical digestion through the actions of the teeth, tongue, and palatal surfaces; (3) lubrication by mixing with mucus and saliva; and (4) limited chemical digestion of carbohydrates and lipids. The oral cavity is lined by the oral mucosa, which has a stratified squamous epithelium The epithelial lining of the cheeks, lips, and inferior surface of the tongue is relatively thin and nonkeratinized. Nutrients are not absorbed in the oral cavity, but the mucosa inferior to the tongue is thin enough and vascular enough to permit the rapid absorption of lipid-soluble drugs THE TONGUE The tongue has four primary functions (1)mechanical digestion by compression, abrasion, and distortion; (2) manipulation to assist in chewing and to prepare food for swallowing; (3) sensory analysis by touch, temperature, and taste receptors; and (4) secretion of mucins and the enzyme lingual lipase. (5) articulation (forming words during speaking) We can divide the tongue into Apex, an anterior body, or oral portion, and a posterior root, or pharyngeal portion. The superior surface, or dorsum, of the body contains a forest of fine projections, the lingual papillae. Along the inferior midline is the frenulum of tongue, or lingual frenulum. The tongue contains two groups of skeletal muscles. The large extrinsic tongue muscles perform all gross movements of the tongue. genioglossus, hyoglossus, styloglossus, and palatoglossus The smaller intrinsic tongue muscles change the shape of the tongue and assist the extrinsic muscles during precise movements, as in speech. The superior and inferior longitudinal, transverse, and vertical muscles are confined to the tongue. Both intrinsic and extrinsic tongue muscles are under the control of the hypoglossal cranial nerves (XII). All muscles of the tongue, except the palatoglossus, receive motor innervation from CN XII, the hypoglossal nerve. Palatoglossus is a palatine muscle supplied by the pharyngeal plexus. For general sensation (touch and temperature), the mucosa of the anterior two thirds of the tongue is supplied by the lingual nerve, a branch of CN V3. For special sensation (taste), this part of the tongue, except for the vallate papillae, is supplied the chorda tympani nerve, a branch of CN VII. The mucosa of the posterior third of the tongue and the vallate papillae are supplied by the lingual branch of the glossopharyngeal nerve(CN IX) for both general and special sensation ANATOMY OF A TOOTH The bulk of each tooth consists of a mineralized matrix similar to that of bone. This material, called dentin, differs from bone in that it does not contain cells Pulp cavity: an interior chamber. The pulp cavity receives blood vessels and nerves through the root canal. Blood vessels and nerves enter the root canal through an opening called the apical foramen to supply the pulp cavity. A layer of cement covers the dentin of the root. Cement protects and firmly anchors the periodontal ligament. The neck of the tooth marks the boundary between the root and the crown, the exposed portion of the tooth that projects beyond the soft tissue of the gingiva. A layer of enamel covers the dentin of the crown. Enamel, which contains calcium phosphate in a crystalline form, is the hardest biologically manufactured substance. TYPES OF TEETH 1. Incisor teeth are blade-shaped teeth located at the front of the mouth. Incisors are useful for clipping or cutting, as when you nip off the tip of a carrot stick. These teeth have a single root. 2.Canine teeth, or cuspid, are conical with a single, pointed cusp. Also known as the “eyeteeth,” because they lie directly under the eye, the canines are used for tearing or slashing. Canines have a single root. 3. Premolar teeth, or bicuspids, have flattened crowns with two prominent rounded cusps. They crush, mash, and grind. Bicuspids have one or two roots. 4. Molar teeth have very large, flattened crowns with four to five prominent rounded cusps adapted for crushing and grinding. You can usually shift a tough nut to your premolars and molars for successful crunching. Molars in the upper jaw typically have three roots while those in the lower jaw usually have two roots. SETS OF TEETH The teeth are collectively called the dentition. Two such dentitions form during development: deciduous and permanent. The first to appear are the deciduous teeth (deciduus, falling off). Deciduous teeth are also called primary teeth, milk teeth, or baby teeth. Most children have 20 deciduous teeth On each side of the upper or lower jaw, the deciduous teeth consist of two incisors, one canine, and a pair of deciduous molars for a total of 20 teeth. These teeth are later replaced by the permanent teeth of the larger adult jaws. The deciduous teeth either fall out or are pushed aside by the eruption, or emergence, of the permanent teeth. THE SALIVARY GLANDS Three major pairs of salivary glands secrete into the oral cavity. These are: oThe large parotid glands oThe sublingual glands oThe submandibular glands Minor salivary glands include some 800–1000 submucosal glands in the oral cavity. The mucous membrane of the mouth and tongue contains many small salivary glands that open directly, or indirectly via short ducts, to the oral cavity. These glands include labial, buccal, and palatal glands in the lips, cheeks, and palate, respectively, and lingual glandsin the tongue, all of which make a small contribution to saliva. THE PHARYNX The pharynx, or throat, is an anatomical space that serves as a common passageway for solid food, liquid, and air. Food normally passes through parts of the pharynx on its way to the esophagus. The esophagus is a hollow muscular tube that then conveys these ingested materials to the stomach. Regions of the pharynx: nasopharynx, oropharynx, and laryngopharynx THE ESOPHAGUS The esophagus is approximately 25 cm in length and has a diameter of about 2 cm at its widest point. The esophagus begins posterior to the cricoid cartilage, at the level of vertebra C6. It is narrowest at this point. The esophagus descends toward the thoracic cavity posterior to the trachea. The esophagus empties into the stomach anterior to vertebra T7. the esophagus normally has three constrictions where adjacent structures produce impressions: • Cervical constriction (upper esophageal sphincter): at its beginning at the pharyngo esophageal junction, approximately 15 cm from the incisor teeth; caused by the cricopharyngeus muscle. • Thoracic (broncho-aortic) constriction:a compound constriction where it is first crossed by the arch of the aorta, 22.5 cm from the incisor teeth, and then where it is crossed by the left main bronchus, 27.5 cm from the THE STOMACH The stomach has the shape of an expanded J A short lesser curvature forms the medial surface of the organ, and a long greater curvature forms the lateral surface. The stomach typically extends between the levels of vertebrae T7 and L3. Four parts: The Cardia: is the smallest region of the stomach. The fundus is the region of the stomach that is superior to the junction between the stomach and the esophagus. The Body is the area of the stomach between the fundus and the curve of the J. The pyloric part (pyloros, gatekeeper) forms the portion of the stomach between the body and the duodenum. It is divided into a pyloric antrum, which is connected to the body, a pyloric canal, which empties into the duodenum, and the pylorus, which is the muscular tissue surrounding the pyloric orifice (stomach outlet). BLOOD SUPPLY
The celiac trunk
Left Gastric The gastroduodenal artery The right gastric artery RGEA (lesser curvature) LGEA (greater curvature THE PANCREAS The pancreas is an elongate, pinkish-gray organ about 15 cm long and weighing about 80 g. It has the following: The head:lies within the loop formed by the duodenum as it leaves the pyloric part. The body:extends toward the spleen. The tail:is short and bluntly rounded. The pancreas is retroperitoneal and is firmly bound to the posterior wall of the abdominal cavity. Arterial blood reaches the pancreas by way of branches of the splenic, superior mesenteric, and common hepatic arteries. The pancreatic arteries and pancreaticoduodenal arteries are the major branches from these vessels. The splenic vein and its branches drain the pancreas. The large pancreatic duct delivers the secretions of the pancreas to the duodenum. In 3–10 percent of the population, a small accessory pancreatic duct branches from the pancreatic duct. When present, the accessory pancreatic duct usually empties into the duodenum independently, outside the duodenal ampulla. THE LIVER The liver is the largest visceral organ, a firm, reddish-brown organ weighing about 1.5 kg. Most of its mass lies in the right hypochondriac and epigastric regions, but it may extend into the left hypochondriac and umbilical regions as well. The versatile liver performs essential metabolic and synthetic functions. On the anterior surface, the falciform ligament marks the division between the organ’s left and right lobes. On the posterior surface of the liver, the impression left by the inferior vena cava marks the division between the right lobe and the small caudate Inferior to the caudate lobe lies the quadrate lobe, sandwiched between the left lobe and the gallbladder. Afferent blood vessels and other structures reach the liver by traveling within the connective tissue of the lesser omentum. They converge at a region called the porta hepatis (“doorway to the liver”). Nearly one-third of the blood supply to the liver is arterial blood from the hepatic artery proper. The rest is venous blood from the hepatic portal vein. THE GALLBLADDER The gallbladder is a hollow, pear-shaped organ that stores and concentrates bile prior to its secretion into the small intestine. This muscular sac is located in a fossa, or recess, in the posterior surface of the liver’s right lobe The gallbladder is divided into three regions: (1) the fundus, (2) the body, and (3) the neck. The cystic duct extends from the gallbladder to the point where it unites with the common hepatic duct to form the bile duct. At the duodenum, the bile duct meets the pancreatic duct before emptying into a chamber called the duodenal ampulla. THE SMALL INTESTINE The small intestine primarily functions in the chemical digestion and absorption of nutrients. The small intestine, also known as the small bowel, averages 6 m (19.7 ft) in length (range: 4.5–7.5 m; 14.8–24.6 ft). Its diameter ranges from 4 cm at the stomach to about 2.5 cm at the junction with the large intestine. The primary blood vessels involved are branches of the superior mesenteric artery and the superior mesenteric vein. THE LARGE INTESTINE The horseshoe-shaped large intestine begins at the end of the ileum and ends at the anus. The large intestine lies inferior to the stomach and liver and almost completely frames the small intestine. The large intestine stores digestive wastes and reabsorbs water. The large intestine, also known as the large bowel, has an average length of about 1.5 meters (4.9 ft) and a width of 7.5 cm. divide it into three segments: (1) the pouchlike cecum, the first portion of the large intestine; (2) the colon, the largest portion; and (3) the rectum, the last 15 cm of the large intestine and the end of the digestive tract THE CECUM AND APPENDIX Material arriving from the ileum first enters an expanded pouch called the cecum. The ileum attaches to the medial surface of the cecum and opens into the cecum at the ileocecal valve. The cecum collects and stores materials from the ileum and begins the process of compaction. The slender, hollow appendix, or vermiform appendix (vermis, worm), is attached to the posteromedial surface of the cecum. The appendix is normally about 9 cm long, but its size and shape are quite variable. The primary function of the appendix is as an organ of the lymphatic system. THE COLON Subdivided the colon into four segments: the ascending colon, transverse colon, descending colon, and Sigmoid colon The colon, and indeed the entire large intestine, receives blood from branches of the superior mesenteric and inferior mesenteric arteries. The superior mesenteric and inferior mesenteric veins collect venous blood from the large intestine. THE RECTUM The rectum forms the last 15 cm of the digestive tract. It is an expandable organ for the temporary storage of feces. The last portion of the rectum, the anal canal, contains small longitudinal folds called anal columns. The distal margins of these columns are joined by transverse folds that mark the boundary between the columnar epithelium of the proximal rectum and a stratified squamous epithelium like that in the oral cavity. THANK YOU