HORMON TIROID (SINTESIS DAN

LABORATORIUM)

R1
 Thyroid hormones are critical for normal growth and sexual development of children.
 In adults, thyroid hormones

a) control the rate of metabolism,

b) biochemical reactions,
c) total body oxygen consumption,
d) heat production,
e) speed of drug metabolism.
 Thyroid-stimulating hormone (TSH) increases the
circulating levels of thyroid hormones, L-thyroxine
(levothyroxine, L-T4) and triiodothyronine (T3).
 L-T4 contains four atoms of iodine while T3 contains
three atoms of iodine per molecule of hormone.
 TSH is made by the anterior pituitary and secreted
into the systemic circulation.
 TSH reaches the thyroid gland to stimulate thyroid
follicular cells to take up iodine via the sodium iodide
symporter, increase synthesis of thyroid hormones
and release thyroid hormones (L-T4 and T3).
 After the iodide is taken up into the thyroid,
thyroperoxidase (TPO) covalently attaches it to the
thyroid hormone precursor protein thyroglobulin.
SINTESIS HORMON TIROID
PEMERIKSAAN LABORATORIUM
TERIMAKASIH