Siriraj International

Medical Microbiology,
Parasitology and
Immunology Competition

Departemen Pendidikan dan Profesi BEM KM FK UNAIR

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Point Acquisition : 10
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A protein that mediate many self protein to be expressed in

epithelial cell of thymus
Kunci : AIRE
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Patients with HLA-DRB1*0301/0401 have greater risk for...

kunci : Type 1 diabetes mellitus
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NOD2 gene may contribute to

Kunci Chron’s disease
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Receptor editing is mediated by......gene

Kunci : RAG
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... produces IL-10-homologous protein which inhibits activation of macrophages

and dendritic cells and may thus suppress cell-mediated immunity.(Clue: name
of virus)
Kunci: EBV
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What cytokine has been shown to be protective in many protozoal

infections, including malaria, toxoplasmosis, and cryptosporidiosis?
Kunci: IFN-gamma
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Individuals with have defective of Th17 responses are susceptible to

mucocutaneous fungal infection of... (genus)
Kunci: Candida
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Macrophages and DCs sense fungal organisms by TLRs and lectin-like

receptors called ... that recognize β-glucans on the surface of the fungi.
Kunci: Dectin
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In immune-mediated inflammation, what cells can secrete

cytokines that recruit and activate leukocytes?
Kunci: Th1 and Th17
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CTLs may be able to distinguish between cytopathic and

noncytopathic viruses, so they only kill cytopathic virus-
infected cells. (T/F)
Kunci: F
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In complexes immune complex–mediated containing anionic

antigens bind avidly to positively charged components of the
basement membranes of blood vessels and kidney glomeruli. (T/F)
Kunci: F
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In chronic DTH reactions, activated macrophages can resemble skin epithelial

cells called...
Kunci: Epithelioid cells
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Grafts which is transplanted between genetically identical

individuals
Kunci : Isografts
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Interferons and TNF-α and -β all increase the expression of

class II MHC molecules in the graft (T/F)
Kunci : F (class I MHC)
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Graft rejection thath occurs within days; with the timing and
mechanism are similar to a memory response is
Kunci : Accelerated Acute Graft Rejection
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Drug that blocking the B7 costimulatory molecule binding to

CD28 is
Kunci : Belatacept (CTLA-4-Ig)
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Mutations in gene encoding the β chain (CD18) of β2

integrins will cause.......
Kunci - Leukocyte adhesion deficiency type 1
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Chédiak-Higashi syndrome occurs when there is

abnormalities in......gene
Kunci ; LYST
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...........(disease) is characterized by defective B cell heavy-chain isotype (class)

switching, so IgM is the major serum antibody, and by deficient cell-mediated immunity
against intracellular microbes.
Kunci : The X-linked hyper-IgM syndrome
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SCID is one of the immunodeficiency. It is caused

by........&........deficiency leads to accumulation of toxic
metabolites in lymphocytes.
ADA, PNP
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Central arterioles of lymph nodes' white pulp are surrounded by cuffs of

lymphocytes known as
PALS
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targeted by ubiquitin and degraded in proteasomes are characteristic of .. pathway of MHC

endogenous
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APC that Initiate of the Th2 response for humoral immunity is

B cell
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Peptides from intracellular pathogens and

altered proteins are transported to
endoplasmic reticulum to be presented on
MHC II (T/F)
False (MHC I)
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antagonist of CTLA-4 that use in melanoma theraphy is..

Ipilimumab
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CTLA-4 is responsible for … by competitive binding to… and …

on APCs.
downregulating the immune response, B7-1, B7-2
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The costimulatory molecules CD80 and CD86 on APCs bind to CD28 on

the mature, naïve T cells, providing the second signal necessary for
activation of T lymphocyte (T/F)
True
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Cytokines secreted by APCs and the activating T cells

themselves induce the proliferation this process also known as
...
clonal expansion
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Soft swelling (wheal) can dilated and become engoreged with

RBC producing red rim called
Kunci : Flare
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Cytokine that have strongest association with asthma also

potent inducer of type 2 inflammation is
Kunci : IL-33
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Mast cells play an important protective role to venoms

(T/F)
Kunci : T
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Allergen generally stimulate Th-1 and Th-17 to induce

cytokine production (T/F)
Kunci : F
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