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Presented by: Dr. Nidhi
Basic Antibody Structure
Types of Antibody
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INTRODUCTION
P region
Multiple germ Combinatorial nucleotide
line genes V(D)J addition
Joining
N region Combinatorial
nucleotide Junctional association of
addition flexibility H and L
chain
Somatic hyper
mutation
Multiple germline segment.
Multiple germ line segment
generate diversity
κ and λ light chains and H chains are
coded by separate multigene families
situated on different chromosome.
Since Ig are product of a multigene
family – different kind of Ig are
produced from different genes.
Human Ig gene pool
Combinatorial V-J (Light chain) and
V-D-J joining (Heavy Chain)
Things to remember
• Ig has heavy chain and light chain