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DISSOLUTION PARAMETERS
PHARMACOKINETICS PARAMETERS
CONSOLIDATION
Cont….
Effect of viscosity of the dissolution medium
Effect of the presence of unreactive and reactive additives
in the dissolution medium.
Volume of dissolution medium and sink conditions
Deaeration of the dissolution medium
Effect of temperature of the dissolution medium
EFFECT OF AGITATION
The relationship between the intensity of agitation and the
rate of dissolution varies considerably according to the
type of agitation used, the shape and design of the stirrer
and the physicochemical properties of the solid.
For the basket method, 100 rpm usually is utilized, while
for the paddle procedure, a 50 – 75 rpm is recommended.
EFFECT OF DISSOLUTION FLUID
PARAMETERS
PHARMACOKINETIC PARAMETERS