अन्तरयाम/मन्यास्तम्भ • मन्ये संश्रित्य वातोअन्तर्यदा नाडीः प्रपध्यते मन्यास्तम्भं तदा कु र्यादन्तरायामसंग्नितम् अन्तरायम्यते ग्रीवा मन्या च स्तभ्यते भ्रुशाम् दन्तानां दशनं लाला प्रुष्टाक्षेपः शिरोग्रहः ज्रुम्भा वदनसंघ्श्चाप्यन्तरायामलक्षणं ( च.चि. २८/४३,४४) बहिरायाम • प्रुष्ट्मन्याश्रिता बाह्याः शोषयित्वा सिरा बली वायुः कु र्याद्दनुस्तम्भं बहिरायामसंग्नयकं चापवन्नाम्यमानस्य प्रुष्ट्तो नीयते शिरः उर उत्क्षिप्यते मन्या स्तब्धा ग्रीवव्यम्रूध्यते दन्तानां दंशनं ज्रुम्बा लालाश्रावश्च वाग्रहः जातवेगो निहन्तन्ये वैकल्यं वा प्रयच्छति ( च. चि. २८/४५-४८) Modern Description • When the tetanic spasm affects the muscles of the head and neck the condition is described as trismus. When the spasm affects the muscles of the back, and pulls the head backwards, the term opisthotonos is applied; in the opposite condition the word emprosthotonos was used to indicate the bending of the body forward, and in cases where the spasm affected one side of the body, causing it to curve to that side, the condition was defined as pleurosthotonos. All these states are recognized in different phases of the disease in the human subject, but they are rarely met with in the horse, with the single exception of the first, described as trismus, which is the most common form. Emprosthotonos • Etymology: Gk, emprosthen, forward, tenein, to cut • A position of the body characterized by forward, rigid flexure at the waist. The position is the result of a prolonged involuntary muscle spasm that is most commonly associated with tetanus infection or strychnine poisoning. Opisthotonus Opisthotonus or opisthotonos, from Greek roots, opistho meaning "behind" and tonos meaning "tension", is a state of a severe hyperextension and spasticity in which an individual's head, neck and spinal column enter into a complete "bridging" or "arching" position.[1] This abnormal posturing is an extrapyramidal effect and is caused by spasm of the axial muscles along the spinal column. Pleurothotonus • Pleurothotonus, also known as Pisa syndrome, refers to an involuntary state of lateral flexion of the thoracic and lumbar spine (hence the reference to leaning tower). It is an extrapyramidal neurological syndrome. • It may occur secondary to chronic administration or overdose of antipsychotic medications, as well as antiemetics चिकित्सा • वायुना वेष्ट्य्माने तु गात्रे स्यादुपनाहनम् (च.चि.२८/९७)
Vaccination • Tetanus can be prevented through the use of an effective vaccine, simple or adsorbed Tetanus vaccine, combined Tetanus and Killed Polio vaccine, or the older DTP (diphtheria, tetanus, pertussis) vaccine. Side effects are rare, but if they do occur, include: • Fever • Pain at the injection site • Unexplained crying in infants, irritability in older children or adults. • Severe reactions are extremely rare and include anaphylaxis, seizures and encephalopathy. These events are thought to occur less if only the tetanus-diphtheria component of the vaccine is given [ citation needed] . It is recommended that all infants receive the vaccine at 2, 4, 6, and 15 months of age. A fifth booster dose should be given at 4-6 years of age. After that, it should be given every 10 years. However, if a bite, scratch, or puncture occurs more than five years after the last dose of vaccine, the patients should receive another dose of vaccine. Treatment • When a tetanus infection becomes established, treatment usually focuses on controlling muscle spasms, stopping toxin production, and neutralizing the effects of the toxin. Treatment includes administration of tetanus immune globulin (TIG), which comprises antibodies that inhibit tetanus toxin (also known as tetanus antitoxins), by binding to and removing unbound tetanus toxin from the body. Binding of the toxin to the nerve endings appears to be an irreversible event, and TIG is ineffective at removing bound toxin. Recovery of affected nerves requires the sprouting of a new axon terminal.[4] Large doses of antibiotics (such as metronidazole or intramuscular doxycycline) are also given once tetanus infection is suspected in order to halt toxin production. Contd… • Prevention of tetanus includes vaccination and cleaning the primary wound. Prophylaxis is effective in the form of a tetanus toxoid vaccine, which is given with or without passive immunization with tetanus immune globulin. Very few cases of tetanus have occurred in individuals with up-to-date tetanus vaccinations. DPT vaccine (diphtheria-pertussis- tetanus) is administered in most of the world. It is given at 2, 4, 6, and 15–18 months of age, followed by a booster before entry to school (4-6 years). This regimen provides protection from tetanus for about 10 years, and every 10 years thereafter, a booster shot of tetanus vaccine is recommended.[2] Attention • Tetanus is not contagious from person to person, and is the only vaccine-preventable disease that is infectious but not contagious. A C. tetani infection does not result in tetanus immunity, and tetanus vaccination should be given as soon as the patient has stabilized