PREPARATION OF ALDEHYDES

1. Oxidation of primary alcohols.

2. Oxidation of methylbenzenes.
PREPARATION OF KETONES
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1 3 1

3
2 2
 0

Methyl amine Di-methyl amine Ethylmethylamine

Tri-methylamine
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CHM 312 Heterocyclic Chemistry
Nomenclature of heterocyclic compounds
Nomenclature of heterocyclic compounds
Five - membered aromatic heterocycles
Five - membered aromatic heterocycles
Non - aromatic heterocycles
Quinolines
Quinolines
The Friedlander Synthesis of Quinoline
An o-aminobenzaldehyde is treated with an aldehyde or ketone in a
basic medium; formation of the imine is followed by dehydrative
cyclisation
Synthesis of Nicotinic Acid from Quinoline

Nicotinic acid is synthesised by the oxidation of quinoline with

Chromium (vi) oxide. Quinoline oxidises to pyridine-2,3-dicarboxylic
acid which readily loses the 2-carboxyl-substituent on being heated to
form nicotinic acid
Derivatives of Quinoline

Chloroquine
CH3

NEt2
HN

Cl
N
Quinine

Structure of Quinine (the Asymmetric Centres are Shown

as *)
Isoquinoline

Isoquinoline is a heterocyclic aromatic organic

compound. It is a structural isomer of quinoline.
Isoquinoline and quinoline are benzopyridines, which
are composed of a benzene ring fused to a pyridine
ring. The nitrogen in isoquinoline is on position 2
while the nitrogen is on position 1 in quinoline