LORAZEPAM

NAME : G . SAI VINEELA

ROLL NO : 23
SUBJECT : MEDICINAL CHEMISTRY
COURSE : B PHARM 3RD YEAR
  INTRODUCTION
 STRUCTURE
 SYNTHESIS
 MECHANISM OF ACTION

CONTENT  STRUCTURE ACTIVITY RELATIONSHIP

 THERAPEUTIC USES
 DOSAGE
 ADVERSE EFFECTS
 INTRODUCTION
LORAZEPAM [ATIVAN]
 Sedatives :  CNS deprassant drugs that reduce excitement , tension and produce
relaxation.
 Hypnotics : depress CNS and produce sleep similar to natural sleep.  Also referred to
as SLEEPING PILLS .
 They cause drowsiness and facilitate the initiation and maintanance of sleep .
 Small doses cause SEDATION .
 Larger doses cause HYPNOSIS
 Still larger doses cause SURGICAL ANESTHESIA
 Lorazepam belongs to the class BENZODIAZEPINES
CLASSIFICATION
BENZODIAZEPINES
STRUCTURE

• Benzo – benzene
• Diaza – 2 nitrogen's
• Epine – 7 membered ring with
unsaturation

 Lorazepam - 
7-Chloro-5-(2 chloro phenyl ) - 3
dihydro – 3 – hydroxy – 2 H – 1,4 –
benzodiazepine –2 one
 M.WT : 321.16
SYNTHESIS
MECHANISM OF ACTION
STRUCTURE ACTIVITY
RELATIONSHIP
THERAPEUTIC USES SIDE
 Sleep disorders EFFECTS
 Drowsiness
 Muscle spasms  Sedation
 Induction of general anesthesia  weakness
 Night mares
 Anxiety  Blurred vision
 Constipation
 Insomnia  Dizziness
 Nausea and vomiting  Head ache
 Aggression
 Depression  Excitement
 Hypotension
 Drug dependence
 DOSAGE
 FOR ANXIETY :
  2-3mg orally/day [2-3
times/day]
 FOR INSOMNIA :
 2-4mg orally once a day at
bedtime
REFERENCES :

 https://journals.lww.com/jan/Citation/2012/05000/Ativan__Lorazepam_.12.aspx
 Ghiasi N, Bhansali RK, Marwaha R
 https://www.ncbi.nlm.nih.gov/books/NBK532890/
 FOYE'S Principles of Medicinal Chemistry