MUTATION

LECTURE BY
J. ARNOL
Review

DNA

RNA
 MUTATION
A permanent change of the nucleotide
sequence of the genome of an organism,
virus, or extra chromosomal DNA or
other genetic elements.
 MUTATION
It results in damage to DNA that is not repaired or
to RNA genomes (typically caused by radiation or
chemical mutagens), errors in the process of
replication, or from the insertion or deletion of
segments of DNA by mobile genetic elements.
MUTATION
 2 TYPES OF GENE MUTATIONS

POINT FRAME-
MUTATIO SHIFT
N MUTATIO
N
1. GENE MUTATIONS
GENE MUTATIONS
2. CHROMOSOMAL MUTATIONS
DELETION
DELETION
2. CHROMOSOMAL MUTATIONS
DUPLICATION
2. CHROMOSOMAL MUTATIONS
INVERSION
2. CHROMOSOMAL MUTATIONS
2. CHROMOSOMAL MUTATIONS
SICKLE CELL ANEMIA

TRANSLOCATION
2. CHROMOSOMAL MUTATIONS
NONDISJUNTION
NONDISJUNTION
NONDISJUNTION
NONDISJUNTION
SHORT
QUIZ
6. FOUR RING INVERSION
7. CHARCOT-MARIE-
TOOTH
8. SICKLE CELL ANEMIA
9. KLINEFELTER'S
SYNDROME
 DELETIO
N
DELETIO
N
NONDISJUNCTION
NONDISJUNCTION
NONDISJUNCTION

6. FOUR RING INVERSION INVERSION

7. CHARCOT-MARIE- DUPLICATION
TOOTH
8. SICKLE CELL ANEMIA TRANSLOCATION
9. KLINEFELTER'S NONDISJUNCTION
SYNDROME
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