How Important is the

Right Formulation for

Topical Drug
Development?
 Topical Formulations
Topical formulations are becoming increasingly popular
in the pharmaceutical industry.

Not only have they allowed the delivery of the drug

substance to a specific site, but they also avoid
fluctuations in drug levels, inter and intra-patient
variations, and improve the patient’s compliance with the
treatment.

In a topical formulation, the skin acts as a perfect

medium for the delivery of the drugs having both local and
systemic effects, but also acts a mechanical barrier for the
penetration of some.
This is so because the ingredients in the topical
applications not only react amongst themselves, but also
with the skin of the patient.

For example, the drug substance used in a psoriasis

treatment may be effective simply due to the hydrating or
soothing effects of the formulation. Whether the molecule
maintains its purity, potency, and delivery to the right target
site may be masked by the ingredients that surround it.

Both the mechanical barrier properties of the top layer of

skin and the physicochemical properties of the drug affect
the transportation of the drug substance from the
formulation to the site of action.
 Thus, to have the desired benefit from
topical applications, their right formulation
is absolutely essential. Even a small change
in the formulation of the topical drugs can
make a huge difference in their efficacy.
 Interesting, right?
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