Professional Documents
Culture Documents
1. Overview:(Gangren–Dry,Wet /Gas)
2. Pathologic Background
3. Causes
4. Risk Factors
5. Symptoms
6. Types(Definition,Causes,Pathophysiology,Features, Morphology)
7. Difference between Dry,Wet and Gas Gangrene
8. Diagnosis
9. Treatment
Gangrene
Dry
Gangrene
Wet(Gas) 1.Cell/Tissue Death
Bacterial
Gangrene (Coagulative Necrosis
+
Infection
2.Tissue Decay
(Putrefaction)
Changes after Cell Death
Due to In In With
Thrombosis
Embolus • Boils • Crush injuries • Burns
Diabetes • Carbuncles • Pressure sores • Frostbite
Buerger’s Disease
• Raynaud’s
disease
Risk Factors
Skin Discoloration ,
Numbness ,
Skin that feels cold or cold to the touch ,
Swelling and pain at the site of infection ,
Fever ,
Foul-Smelling pus leaking from a blister or sore ,
Shiny appearance to the skin ,
Septicemia(Blood Poisoning or Spreading of infection by blood as in Wet Gangrene) , and
Crepitation/Production of Crackling sound when you press on your skin (this signals
there’s a buildup of gas in your tissue in case of Gas Gangrene).
Types of Gangrene
4. Ischemia
6. Necrosis (Coagulative)
7. Dry Gangrene
Why we call it Dry Gangrene?
Clear Line of
Demarcation between
Healthy and Gangrenous
Blockage in Tissue
Artery Proximal
Portion
Distal Portion
Features
1. Arterial Occulsion
2. Slow Infection
3. No/less Systemic infection(Transferable from one organ to other)
4. No septicemia
Morphology of Dry Gangrene
Grossly, affected part is
Dry,
Shrunken, and
Dark black resembling the foot of a mummy.
Infectious
Bacteria
Proximal
Portion Distal Portion
Peripheral
Arteries Gangrenous Tissue
Blockage in Vein
Features
1. Venous Blockage
2. Rapid Infection
3. Systemic infection(Transferable from one organ to other)
4. Septicemia
Morphology of Wet Gangrene
Main Cause
It is caused by gas-forming clostridia (gram-positive anaerobic bacteria) e.g
Clostridium perfringens .
which gain entry into the tissues through open contaminated wounds, especially
in the muscles, or as a complication of operation on colon which normally
contains clostridia.
They release dangerous toxins or poisons, along with gas that can be trapped in
tissue.
Skin may become pale and gray.
Why we call it Gas Gangrene?
No Clear Line of
Demarcation between
Healthy and Gangrenous
No Blockage in Tissue
Artery
Clostridia
Proximal Perfringens
Distal Portion
Portion
Blockage in Vein
Peripheral
Arteries Gangrenous Tissue
Features
1. Venous Blockage
2. Rapid Infection(e.g Clostridium Perfringens)
3. Systemic infection(Transferable from one organ to other)
4. Septicemia
5. Crepitation (due to CO2 formation).
Morphology of Gas Gangrene
Treatment options may depend on the severity of your gangrene. Usually, tissues that
have been damaged by gangrene cannot be saved, but steps can be taken to reduce the
progression of your condition.
Antibiotics that are given intravenously or taken orally.
Surgery to remove dead tissues which may help to stop gangrene from spreading
and allows healthy tissue to heal
If possible, damaged or diseased blood vessel may be repaired in order to increase
blood flow to the affected area.
In severe cases, an affected body part may need to be amputated.
Hyperbaric oxygen therapy may also be used. In this type of treatment, you are
placed in a specially designed chamber filled with oxygen at a high Pressure than the
one found in the outside air.
The theory is that blood rich in oxygen slows the growth of bacteria and helps
infected wound heals more easily.