Iron metabolism and it’s

regulation

Name: Suraj Kafle

Semester: Fourth
Symbol No: 20760039
Program: Bsc.MLT
Date: 2079-7-17
 Content

 Introduction
 Metabolism
 Regulation
 Reference
 Introduction
• It is trace element
• Total iron content is 3-5g.
• 65% in Haemoglobin
• 5% in Myoglobin
• 30% in ferritin(storage form of iron)
Metabolism
• Iron is absorbed in Heme form, Ferric and Ferrous form.
• Absorbed in duodenum.
• Heme form binds with heme receptor and enters, since haem iron is
in ferrous form.
• Ferric form is converted to ferrous form by duodenal cytochrome B.
• Enters through Divalent metal transporter(DMT).
• Since the free iron is toxic.
• It is stored by forming complex
• known as ferritin and hemosiderin.
• Iron is exported to circulation through ferroportin (iron exporter).
• Since ferric form of iron only found in circulation.
• Ferrous form is converted to ferric form by hephaestin.
• Iron perform different function in human body.
• So, it is transported to different part of the body by binding to a
protein called Transferrin.
• One transferrin binds 2 iron.
• 65% of of iron is transported to bone marrow and binds with
transferrin receptor and get release into bone marrow.
• RBC is formed and after 120 days the RBC is dead and iron is release
in circulation.
• 30% of iron is transported to liver and stored in ferritin and
hemosiderin(complex molecule).
Regulation
• Liver releases a protein called hepcidin.
• Hepcidin block the ferroportin channel.
• By this iron can’t reach to circulation.
• So it regulates iron concentration and maintain homeostasis of iron.
• In case of anaemia level of iron is low so hepcidin is low which allow
iron to circulate more in circulation
Reference
• https://www.youtube.com/watch?v=TwJ0DuI2-lc&t=140s&ab_channe
l=MEDBRAIN
• https://www.youtube.com/watch?v=ftUtEhQBWZs&ab_channel=deva
nshclassroommedicallectures
THANK YOU